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The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients
Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure.
The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.
Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute decompensated heart failure (de novo or as decompensation of chronic heart failure) | This umbrella term includes patients presenting forthe first time with typical symptoms and signs of heart failure(de novo AHF) and also those with worsening of their pre-existing cardiomyopathy (acute decompensated heart failure). |
| |
| Pulmonary edema | It's the real clinical presentation of AHF, typically, signs and symptoms develope rapidly and patients demonstrate severe respiratory distress with tachypnea, orthopnea and pulmonary congestion |
| |
| Hypertensive acute heart failure | the condition is associated with elevated blood pressure with accompanying dyspnea. orthopnea and pulmonary congestion, often in patients with relatively preserved left ventricle ejection fraction |
| |
| cardiogenic shock | severe peripheral hypoperfusion wih subsequent end organs damage,typically it's associated with low blood pressure and low urine output |
| |
| Acute coronary syndrome complicated by heart failure | characterized by complex structural, hemodynamic and neurohormonal interaction need urgent referral for coronary intervention poor outcome |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Avoiding the risk factors | Behavioral | Exercise, Salt and lipid reduction in diet, smoking cessation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals | assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals | assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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patients aged 18 yrs or older presenting with AHF
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sara Mohamed | Contact | +201117517685 | Sara_mohamed_post@med.Sohag.edu.eg | |
| Hassan Ahmed | Contact | +201003459741 |
| Name | Affiliation | Role |
|---|---|---|
| Hamdy Saad | Sohag University | Study Chair |
| Haitham Mohammad | Sohag University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university | Sohag | Egypt |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Aug 10, 2025 | |
| Reset | Aug 27, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Aug 10, 2025 | Aug 27, 2025 |
| ID | Term |
|---|---|
| D006467 | Hemophilia A |
| ID | Term |
|---|---|
| D025861 | Blood Coagulation Disorders, Inherited |
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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|
| D020147 | Coagulation Protein Disorders |
| D006474 | Hemorrhagic Disorders |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |