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It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fractionated Laser Resurfacing | Experimental | At 14 days prior to scheduled surgery a 5x5cm square on the left abdomen within the region of skin to be excised and treated with fractionated laser resurfacing. Then at 7 days prior to scheduled surgery a 5 cm diameter circle on the right abdomen within the region of skin to be excised, at least 10 cm away from the square, is treated with fractionated laser resurfacing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fractionated Laser Resurfacing | Device | A rejuvenating laser that makes tiny holes in the very superficial part of the skin. |
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| Measure | Description | Time Frame |
|---|---|---|
| To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes. | Identify cells in the skin that have been wounded by FLR at 2 weeks and 1 week previously, for cells that co-express markers for both fibroblasts and monocytes by using single cell RNA-sequencing | 2 weeks prior to skin removal and 1 week prior to skin removal |
| To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis). | Using tissue RNA-seq, PI will define if co-expressing cells are in the papillary dermis. | 2 weeks prior to skin removal and 1 week prior to skin removal |
| Measure | Description | Time Frame |
|---|---|---|
| To define the number and types of cells populating the skin following fractionated laser resurfacing (FLR) wounding | Define the number and types of cells following FLR wounding at 2 weeks and 1 week prior to skin removal by using single-cell RNA-seq. | 2 weeks prior to skin removal and 1 week prior to skin removal |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manager, Clinical Research Operations | Contact | 937-245-7500 | pturesearch@wrightstatephysicians.org | |
| Regulatory Specialist | Contact | 937-245-7500 | pturesearch@wrightstatephysicians.org |
| Name | Affiliation | Role |
|---|---|---|
| Jeffrey Travers, MD, PhD | Wright State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pharmacology Translational Unit | Recruiting | Fairborn | Ohio | 45324 | United States |
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| ID | Term |
|---|---|
| D012878 | Skin Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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All subjects will receive fractionated laser resurfacing.
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| To define the locations of the number of cells populating in the skin following fractionated laser resurfacing (FLR) wounding |
Define the locations of the number cell following FLR wounding at 2 weeks and 1 week prior to skin removal by using tissue RNA-seq. |
| 2 weeks prior to skin removal and 1 week prior to skin removal |
| To define the locations of the types of cells populating in the skin following fractionated laser resurfacing (FLR) wounding | Define the locations of the different cell types following FLR wounding at 2 weeks and 1 week prior to skin removal by using tissue RNA-seq. | 2 weeks prior to skin removal and 1 week prior to skin removal |