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Insomnia is prevalent in the global population. Diamino oxidase (DAO) is an enzyme that degrades histamine. When there is not enough DAO enzyme activity in the body, histamine accumulates and it can lead to symptoms in the nervous system, among others. In this study we wanted to study the prevalence of DAO deficiency in pacients with insomnia symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with insomnia symptoms | Patients with insomnia symptoms visiting AdSalutem sleep center |
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| Measure | Description | Time Frame |
|---|---|---|
| number of patients with insomnia symptoms and DAO deficiency | number (absolute and percentage) of patients with insomnia symptoms and DAO deficiency | at the time of enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with insomnia symptoms attending AdSalutem sleep center
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| Name | Affiliation | Role |
|---|---|---|
| Julia Ferrer Garcia, MSc | AdSalutem Sleep Institute | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AdSalutem Sleep Institute | Barcelona | Barcelona | 08008 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30836736 | Background | Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019 Jul;17(3):427-433. doi: 10.5217/ir.2018.00152. Epub 2019 Mar 7. | |
| 17826755 | Background | Garcia-Martin E, Ayuso P, Martinez C, Agundez JA. Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals. Clin Biochem. 2007 Nov;40(16-17):1339-41. doi: 10.1016/j.clinbiochem.2007.07.019. Epub 2007 Aug 11. |
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Antropometric data
According to legislation
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| ID | Term |
|---|---|
| D007319 | Sleep Initiation and Maintenance Disorders |
| ID | Term |
|---|---|
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
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| 17700358 | Background | Ayuso P, Garcia-Martin E, Martinez C, Agundez JA. Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. Pharmacogenet Genomics. 2007 Sep;17(9):687-93. doi: 10.1097/FPC.0b013e328012b8e4. |
| 39200725 | Derived | Lopez Garcia R, Ferrer-Garcia J, Sansalvador A, Quera-Salva MA. Prevalence of Diamine Oxidase Enzyme (DAO) Deficiency in Subjects with Insomnia-Related Symptoms. J Clin Med. 2024 Aug 6;13(16):4583. doi: 10.3390/jcm13164583. |
| D001523 |
| Mental Disorders |