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| ID | Type | Description | Link |
|---|---|---|---|
| C3/22/050 | Other Grant/Funding Number | KU Leuven |
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A new dietary assessment method was developed based on the Experience Sampling Methodology. In order to use this newly developed Experience Sampling Dietary Assessment Method (ESDAM) in research and clinical practice as a valid and reliable method to measure dietary intake the ESDAM needs to be validated against objective biomarkers and reference methods.
The purpose of this research project is to advance nutritional research by delivering an improved, accurate, feasible and reliable method to assess dietary intake. Our newly developed approach to collate dietary intake based on experience sampling methodology (ESM) will serve this purpose.
Therefore, this research aims to validate the newly developed Experience Sampling Dietary Assessment Method (ESDAM) by assessing construct validity compared to blood and urine biomarkers representing dietary intake. This will eventually result in the newly developed dietary assessment method being evidence-based and validated and, thus, ready-to-use as a reliable method for research and clinical practice.
Therefore, the ESDAM will be validated against repeated 24-hour dietary recalls, the doubly-labelled water method, urinary nitrogen and blood biomarkers. The study has a duration of four weeks. The first two weeks will be used to collect baseline data including socio-demographic, biometric data and three 24-hour recalls to assess dietary intake. During the last two weeks the Experience Sampling Dietary Assessment Method will be evaluated against urine biomarkers (Doubly-labeled water and urinary nitrogen), blood biomarkers (erythrocyte membrane fatty acid composition, beta-carotenoids, polyphenols) together with continuous glucose monitoring and two wrist-worn motion sensor devices to track eating- related movements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| YONAS 1 | ESDAM validation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ESDAM validation | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Daily dietary energy intake based on the Experience Sampling Dietary Assessment Method | Daily dietary energy intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to the Doubly-labeled Water Method | 2 weeks |
| Daily dietary protein intake based on the Experience Sampling Dietary Assessment Method | Daily dietary protein intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to urinary nitrogen | 2 weeks |
| Daily energy expenditure derived from the doubly-labeled water method | Daily energy expenditure (kcal/day) measured by the doubly-labeled water method | 2 weeks |
| Daily dietary protein intake based on urinary nitrogen analysis | Daily dietary protein intake based on urinary nitrogen analysis | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Dietary intake based on Experience Sampling Dietary Assessment Method | Daily nutrient and food group consumption estimated by the Experience Sampling Dietary Assessment Method ESDAM | 2 weeks |
| Dietary intake based on 24-hour dietary recalls |
| Measure | Description | Time Frame |
|---|---|---|
| Timing of glucose peaks | Timing of glucose peaks registered by Continuous Glucose Monitoring | 2 weeks |
| Timing of eating-related motion | Timing of eating-related motion monitored by wrist-worn motion sensors |
Inclusion Criteria:
Exclusion Criteria:
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Healthy adult volunteers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christophe Matthys, PhD | Contact | +32 16 34 26 55 | christophe.matthys@uzleuven.be |
| Name | Affiliation | Role |
|---|---|---|
| Christophe Matthys, PhD | KU Leuven/UZ Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KU Leuven | Recruiting | Leuven | Vlaams Brabant | 3000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41194100 | Derived | Verbeke J, Verbeke K, Van der Schueren B, Vangoitsenhoven R, Matthys C. Protocol of the validation of the experience sampling-based dietary assessment method (ESDAM) against doubly labeled water, urinary protein, and biomarkers. Nutr J. 2025 Nov 5;24(1):169. doi: 10.1186/s12937-025-01232-3. |
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Whole blood
|
Energy, nutrient and food group consumption measured by the 24-hour dietary recalls
| 2 weeks |
| Serum Beta-carotenoid concentration | Serum Beta-carotenoids as biomarker of fruit and vegetable consumption | 4 weeks |
| Erythrocyte membrane fatty acid composition | Erythrocyte membrane fatty acid composition as biomarker of fatty acid consumption | 4 weeks |
| Plasma polyphenol concentration | Plasma polyphenol concentration as an indication of dietary polyohenol intake | 4 weeks |
| 2 weeks |