Ibuprofen Use on Post-operative Pain Following Cholecystectomy

Ibuprofen Use on Post-operative Pain Following Cholecystectomy

In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen.

Ibuprofen is a widely used NSAID that has antipyretic, analgesic, and anti-inflammatory effects. In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.The participants in this study were randomized into two groups. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen. The investigators recorded demographic data including gender, age, ASA, BMI, duration of anesthesia and surgery, poNV, LOS, VAS scores and opioid consumption postoperatively.

Inclusion Criteria:

• ASA grade I-II patients
• Aged 18-65 years

Exclusion Criteria:

• History of allergies or hypersensitivity to the aforementioned agents
• Renal, hepatic or gastrointestinal disease
• Significant cognitive impairment
• Recent use of long-term nonsteroid anti-inflammatory and opioids
• Oral anticoagulant use or known bleeding disorders
• Diabetes or any other neuropathic diseases
• Pregnancy or breastfeeding