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The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Premenopausal Female Athletes |
| ||
| Postmenopausal Female Athletes |
| ||
| Male Athletes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress Echocardiogram | Diagnostic Test | Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial stiffness | Myocardial stiffness will be measured by magnetic resonance elastography (kPa) | Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular filling pressures with exercise | Left ventricular filling pressures with exercise will be measured by stress echocardiography | Baseline |
| Exercise capacity | Exercise capacity will be measured by stress echocardiography |
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Inclusion Criteria:
Exclusion Criteria:
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Masters athletes (40-70 yrs of age) with a longstanding history of competitive endurance athletic performance defined as >15 years of continuous athletic training for at least 7 hours per week, and ongoing engagement in competitive events, will be recruited from Mayo registry and from the local athletic community via brochures within the Dan Abraham Healthy Living Center and the Mayo Clinic Classifieds.
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| Name | Affiliation | Role |
|---|---|---|
| Kathryn Larson, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Rochester | Minnesota | 55905 | United States |
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| Cardiovascular Magnetic Imaging (cMRI) | Diagnostic Test | Non-invasive imaging scan used to examine function and structure of the heart |
|
| Cardiac Magnetic Resonance Elastography (cMRE) | Diagnostic Test | Non-invasive imaging scan used to measure myocardial stiffness |
|
| Baseline |
| ID | Term |
|---|---|
| D025401 | Echocardiography, Stress |
| ID | Term |
|---|---|
| D004452 | Echocardiography |
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
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