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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Petroleum gel (Vaseline) | Placebo Comparator | control group |
|
| Lip hydrant | Active Comparator | experimental group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lip hydrant | Other | lip hydrant containing peppermint oil, perilla frutescens, and Emblica fruit extract or petroleum gel. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Objective evaluation | Objective evaluation; using
| 30 minutes per 1 participant |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective evaluation | will be assessed at day 0 (baseline), day 1 and day 28 by using a self-reported questionnaire in scale from 1-10 points for patient's dry lip score which higher score means more dry lip feeling | 5 minutes per 1 participant |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of dentistry, Chulalongkorn university | Bangkok | 10330 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33258166 | Background | Tamura E, Ishikawa J, Yasuda Y, Yamamoto T. The efficacy of synthetic pseudo-ceramide for dry and rough lips. Int J Cosmet Sci. 2021 Apr;43(2):158-164. doi: 10.1111/ics.12677. Epub 2021 Mar 31. | |
| 31571236 | Background | Tamura E, Yasumori H, Yamamoto T. The efficacy of a highly occlusive formulation for dry lips. Int J Cosmet Sci. 2020 Feb;42(1):46-52. doi: 10.1111/ics.12583. |
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| ID | Term |
|---|---|
| D002613 | Cheilitis |
| ID | Term |
|---|---|
| D008047 | Lip Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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This randomized, double-blind, controlled trial will be conducted at the Faculty of Dentistry, Chulalongkorn University. The 66 participants will be randomly assigned to receive either lip hydrant containing peppermint oil, perilla frutescens, and Emblica fruit extract or petroleum gel. Both lip products will be given to allocated participants in the product container of identical appearance. Both subjects and investigators will be blinded to the study randomization.
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| Petroleum gel | Other | Vaseline |
|
| 20725584 | Background | Trookman NS, Rizer RL, Ford R, Mehta R, Gotz V. Clinical assessment of a combination lip treatment to restore moisturization and fullness. J Clin Aesthet Dermatol. 2009 Dec;2(12):44-8. |
| 40013415 | Derived | Sutthiboonyapan P, Sriratanasak N, Innets B, Angkanaporn N, Suntornchot P, Panyain W, Porntaveetus T, Wiriyakijja P, Chanvorachote P. A Randomized Double-Blind Controlled Evaluation of the Therapeutic Benefits of an Herbal Lip Hydrant. J Cosmet Dermatol. 2025 Mar;24(3):e70041. doi: 10.1111/jocd.70041. |