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This study consisted of three sub-studies including 1) development and evaluation of facial serum from Thai rice on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Thai rice on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Thai rice on controlling blood glucose and endurance time in healthy participants.
Study 1: 30 male and female participants, age 30-50 years will be randomly applied with facial serum producing from either 2% alpha albutin (standard facial serum) or Tubtim Chumphae rice extract on either right side or left side of their face daily for 12 weeks.
Study 2: 60 male and female participants, age 30-50 years will be randomly assigned into 2 groups including 1) control group (n = 30): participants will not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants will be applied with home-based program facial mask with Hom Pathum rice extract for 30 min/day, 2 days/week for 12 weeks.
Study 3: this study consists of 2 sub-studies. Study 3.1: 25 male and female participants, age 18-35 years will be randomly consumed with control jelly, jelly with Tubtim Chumphae rice, and jelly with Hom Pathum rice at 3.5 g/kg body weight. All participants will be measured for blood glucose levels before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: 25 male and female participants, age 18-35 years will be randomly consumed with control jelly, jelly with Tubtim Chumphae rice, and jelly with Hom Pathum rice at 3.5 g/kg body weight. After each consumption, all participants will perform walking or running on treadmill at intensity of 80% maximal heart rate to measure maximal oxygen consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study 1: Facial serum with alpha albutin | Active Comparator | Participants will be randomly applied with home-based program of facial serum producing from 2% alpha albutin (standard facial serum) on either right side or left side of their face daily for 12 weeks. |
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| Study 1: Facial serum with Tubtim Chumpae rice extract | Experimental | Participants will be randomly applied with home-based program of facial serum producing from Tubtim Chumpae rice extract on either right side or left side of their face daily for 12 weeks. |
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| Study 2: Facial mask with Hom Pathum rice extract | Experimental | Participants will receive home-based program of facial mask with Hom Pathum rice extract for 30 min/day, 2 days/week for 12 weeks. |
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| Study 3: Control jelly | Active Comparator | Participants will consume with control jelly at 3.5 g/kg body weight. Consumption will be taken at Burapha University. |
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| Study 3: Jelly with Tubtim Chumpae rice | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Study 1: Facial serum with alpha albutin | Other | Applying with facial serum with 2% alpha albutin as active comparator daily for 12 weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| Level of skin moisture | Studies 1 and 2 determine level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe. | Before intervention, immediately after intervention, ends of week 4, week 8, and week 12] |
| Level of skin elasticity | Studies 1 and 2 determine level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe. | Before intervention, immediately after intervention, ends of week 4, week 8, and week 12] |
| Level of skin oiliness | Studies 1 and 2 determine level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe. | Before intervention, immediately after intervention, ends of week 4, week 8, and week 12] |
| Level of skin melanin | Studies 1 and 2 determine level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe. | Before intervention, immediately after intervention, ends of week 4, week 8, and week 12] |
| Level of blood glucose | Study 3.1 determines level of blood glucose in mg/dL unit | Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes |
| Level of maximal oxygen consumption | Study 3.2 determines level of maximal oxygen consumption in mL/kg/min unit by walking or running on treadmill at intensity of 80% maximal heart rate. | After jelly consumption for 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Piyapong Prasertsri, Ph.D. | Burapha University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Piyapong Prasertsri | Mueang | Changwat Chon Buri | 20131 | Thailand |
There is no plan to make individual participant data available to other researchers.
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Study 1 is single group model, study 2 is parallel model, and study 3 is crossover model.
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Participants will consume with Tubtim Chumpae rice jelly at 3.5 g/kg body weight. Consumption will be taken at Burapha University.
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| Study 3: Jelly with Hom Pathum rice | Experimental | Participants will consume with Hom Pathum rice jelly at 3.5 g/kg body weight. Consumption will be taken at Burapha University. |
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| Study 1: Facial serum with Tubtim Chumpae rice extract | Other | Applying with facial serum with Tubtim Chumpae rice extract as experimental intervention daily for 12 weeks. |
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| Study 2: Facial mask with Hom Pathum rice extract | Other | Applying with facial mask with Hom Pathum rice extract as experimental intervention for 30 min/day, 2 days/week for 12 weeks. |
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| Study 3: Control jelly | Other | Consumption with control jelly as active comparator at 3.5 g/kg body weight. |
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| Study 3: Jelly with Tubtim Chumpae rice | Other | Consumption with jelly with Tubtim Chumpae rice as experimental intervention at 3.5 g/kg body weight. |
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| Study 3: Jelly with Hom Pathum rice | Other | Consumption with jelly with Hom Pathum rice as experimental intervention at 3.5 g/kg body weight. |
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| Concentration of interferon-gamma | Study 3.2 determines concentration of interferon-gamma in serum in pg (picogram)/mL unit | Before and immediately after maximal oxygen consumption test |
| Concentration of tumor necrosis factor-alpha | Study 3.2 determines concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit | Before and immediately after maximal oxygen consumption test |
| Concentration of interleukin-10 | Study 3.2 determines concentration of interleukin-10 in serum in pg (picogram)/mL unit | Before and immediately after maximal oxygen consumption test |
| Level of superoxide dismutase activity | Study 3.2 determines level of superoxide dismutase activity in percentage (%) unit | Before and immediately after maximal oxygen consumption test |
| Concentration of malondialdehyde | Study 3.2 determines concentration of malondialdehyde in micromolar (uM) unit | Before and immediately after maximal oxygen consumption test |