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COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters.
Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.
Three types single leg exercise intervantion will applied to COPD patients that devided three groups. One leg continuous exercise training will be aplied to one group. One leg HIIT exercise training will be aplied to other group. One leg resistance exercise training will be aplied to the last group.
Exercise capacity and muscle strength are assesed. Lung function is measured. Electormyography is recorded. Lactate and quality of life are measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single leg resistance exercise intervantion in COPD | Active Comparator | single leg resistance exercise intervantion in COPD will be perfomed at six weeks |
|
| single leg continous exercise intervantion in COPD | Active Comparator | single leg continous exercise intervantion in COPD will be perfomed at six weeks |
|
| single leg high intensity exercise intervantion in COPD | Active Comparator | single leg high intensity exercise intervantion in COPD will be perfomed at six weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| single leg exercise intervantion in COPD | Other | single leg exercise intervantions
|
| Measure | Description | Time Frame |
|---|---|---|
| six minute walk test | six minute walk test in meter | pre-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| cardiopulmonary exercise test | VO2 as ml/kg/min will be recorded from incremental cycle cpet test | beginning day 2 |
| one leg cardiopulmonary exercise test | VO2 as ml/kg/min will be recorded from incremental cycle cpet test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| elif kocaaga, Ms | Contact | +903123052525 | elifkocaaga86@gmail.com | |
| elif kocaaga, Ms | Contact | +903123052525 | elifkocaaga86@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| elif kocaaga, ms | Hacettepe University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Elif Kocaaga | Recruiting | Ankara | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17925417 | Background | Dolmage TE, Goldstein RS. Effects of one-legged exercise training of patients with COPD. Chest. 2008 Feb;133(2):370-6. doi: 10.1378/chest.07-1423. Epub 2007 Oct 9. | |
| 26291542 | Background | Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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three different type one leg exercise intervention are apllied in patients with copd
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|
| beginning, day 3 |
| quadriceps muscle strength assesing (repeated measeure) | quadriceps muscle 10 repeated max muscle strength will be recorded at kilogram, | beginning day 1 and last day |
| isometrics quadriceps muscle strength assesing | quadriceps muscle isometric muscle strength will be recorded at kilogram | beginning day 1 and last day |
| lung function | FEV1/FVC ratio in % | beginning day 1 and last day |
| quality of life assesing | total score in 0-100 range | beginning day 1 and last day |
| arterial stiffness | total vascular resitance, augmentation index @ 75 and pulse wave velocity wil be determined arterial stiffness | beginning day 2 and last day |
| lactate measurement | lactate in mmol | beginning day 2 and last day |
| electromyography measurement | precentage of maximum volunteer contraction) %MVC values will be presented muscle fatigue (median frequence) and activation will be shown electromyograpy (EMG) | beginning day 2 and last day |
| 28497384 | Background | MacInnis MJ, Morris N, Sonne MW, Zuniga AF, Keir PJ, Potvin JR, Gibala MJ. Physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities. Eur J Appl Physiol. 2017 Jul;117(7):1423-1435. doi: 10.1007/s00421-017-3635-8. Epub 2017 May 11. |
| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |