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The goal of this clinical trial is to carry out a clinical description of a Reunionese series of patients (aged 0 to 18 inclusive) with Fetal Alcohol Spectrum Disorders followed up in the Genetics Department of the University Hospital in Reunion Island The aim is also to identify a specific "epigenetic signature" for Fetal Alcohol Spectrum Disorder, in order to provide early diagnostic markers, determine the origin of the microRNAs identified and study the phenotypic-epigenetic relationship (microRNAs).
This research is descriptive and monocentric.
For the 18 patients in the Fetal Alcohol Spectrum Disorder group, the doctor will take a blood sample (for genetic testing) during a scheduled consultation. A remaining 4 ml of blood will be collected for research purposes (Fetal Alcohol Spectrum Disorder group only). A buccal smear will also be taken for research.
For the 18 participants in the control group (healthy participants of the same age and sex as the Fetal Alcohol Spectrum Disorder group), only a buccal smear will be taken for research purposes during a consultation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients Fetal Alcohol Spectrum Disorder | Experimental | Patients with Fetal Alcohol Spectrum Disorder, male an female, aged 0 to 18 inclusive. |
|
| Participants without Fetal Alcohol Spectrum Disorder | Active Comparator | Participants without Fetal Alcohol Spectrum Disorder, male an female, aged 0 to 18 inclusive. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extraction of microRNAs extracted from plasma (4 ml recovered as part of treatment) | Diagnostic Test | Comparison of these micro RNAs with the micro RNAs extracted from oral swabs (in Fetal Alcohol Spectrum Disorder group) |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical description of a series of Fetal Alcohol Spectrum Disorder patients from Reunion Island (part 1) | Description of :
| 6 months |
| Clinical description of a series of Fetal Alcohol Spectrum Disorder patients from Reunion Island (part2) | Description of :
| 6 months |
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Inclusion Criteria:
Fetal Alcohol Spectrum Disorder group :
Control group :
Exclusion Criteria:
Fetal Alcohol Spectrum Disorder group :
Control group :
- people who are not matched on the age and sex of the Fetal Alcohol Spectrum Disorder patients sampled
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de la Réunion | Saint-Denis | 97400 | France |
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This research is descriptive and monocentric research.
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| Extraction of microRNAs extracted from bucal swabs (act added for research). | Diagnostic Test | Comparison of the microRNAs extracted from the oral swabs of the Fetal Alcohol Spectrum Disorder group with the microRNAs extracted from the oral swabs of the without Fetal Alcohol Spectrum Disorder group |
|
| ID | Term |
|---|---|
| D063647 | Fetal Alcohol Spectrum Disorders |
| ID | Term |
|---|---|
| D005315 | Fetal Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D020751 | Alcohol-Induced Disorders |
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
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