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| Name | Class |
|---|---|
| Regionshospitalet Viborg, Skive | OTHER |
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Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
The use of programmed frozen embryo transfer cycle (FET) in IVF women is associated with an increased risk of obstetric complications (pregnancy-induced hypertension, preeclampsia, postpartum hemorrhage and placenta accreta) compared to FET in natural cycle.
The lack of corpus luteum in programmed cycles and the subsequent absence of circulating vasoactive substances may lead to an impaired cardio-vascular adaption to pregnancy and thereby an increased risk of pregnancy-induced hypertension and preeclampsia.
The cardiovascular and metabolic adaption to pregnancy is evaluated throughout pregnancy by use of Magnetic Resonance Imaging (MRI) as well as non-invasive measurements by use of elastography and seismocardiography.
Patients are screened for preeclampsia throughout pregnancy with measurements of blood pressure, urine samples as well as blood samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IVF-pregnancy achieved following modified natural FET cycle, autologous embryo transfer | One corpus luteum, control group, autologous embryo transfer |
| |
| IVF-pregnancy achieved following programmed FET cycle, autologous embryo transfer | No corpus luteum, study group, autologous embryo transfer |
| |
| IVF-pregnancy achieved following egg donation in a FET cycle | One corpus luteum or no corpus luteum, study group, donor egg recipient. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| magnetic resonance imaging (MRI) | Other | MRI performed three times during pregnancy and 6 months postpartum |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maternal cardiovascular adaption to pregnancy | From early pregnancy to six months postpartum | |
| Maternal metabolic adaption to pregnancy | From early pregnancy to six months postpartum | |
| Placental function and fetal oxygenation estimated by longitudinal T2* weighted placental and fetal MRI | From early pregnancy to six months postpartum |
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Inclusion Criteria:
Exclusion Criteria:
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IVF-patients from The Fertility Unit Aalborg University Hospital and The Fertility Clinic, Skive Regional Hospital, Denmark.
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| Name | Affiliation | Role |
|---|---|---|
| Lise H Thomsen, MD, PhD | Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark | Study Chair |
| Anne N Sørensen, MD, PhD | Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark | Study Chair |
| Ulrik Kesmodel, Professor | The Fertility Unit, Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark | Study Chair |
| Peter Humaidan, Professor | The Fertility Clinic, Department of Obstetrics and Gynecology, Skive Region Hospital, Denmark | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg University Hospital | Aalborg | 9000 | Denmark |
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Serum
|
| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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