Medications With or Without WeightWatchers

Effectiveness of a Telehealth Medical Weight Management Program Prescribing Anti-obesity Medications Paired With a Digital Behavioral Weight Management Program

The study compares the effectiveness of adults living with overweight or obesity taking weight management medications alone vs taking them with behavioral and lifestyle support. The primary outcome is percent body weight lost at 12-weeks.

Inclusion Criteria:

• BMI of >30 or BMI of >27 with one or more weight related medically qualifying condition (hypertension, dyslipidemia, sleep apnea, cardiovascular disease)
• Determined eligible for Bupropion/Naltrexone or Liraglutide by WW Clinic medical provider and initiated a medication management plan

Exclusion Criteria:

• Diabetes
• Uncontrolled hypertension
• History of seizures
• History of glaucoma
• History of chronic kidney disease
• Currently taking bupropion
• Currently taking naltrexone
• Current or previous history of anorexia or bulimia nervosa
• Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight
• Currently taking opioids
• Previous surgical obesity treatment
• Use of other anti-obesity medication in last 90 days or a GLP1 in the last 180 days
• Lost weight >11 lbs in the last 90 days
• Pregnant, breastfeeding, intends to become pregnant, of child-bearing potential and not using a highly effective contraceptive method
• Any other reason rendering a participant unsuitable for trial participation, as determined by a clinician or study investigator