The study "AI-Guided (GenAIS TM) Versus Standard Physician-Guided Dietary Supplementation for Managing Metabolic Syndrome" aimed to compare the effectiveness of AI-guided dietary supplement (DS) prescriptions versus standard physician-guided prescriptions in managing metabolic syndrome. This 6-month randomized controlled trial included 160 participants diagnosed with metabolic syndrome. Participants were divided into two groups: one received DS based on physician judgment, and the other based on GenAIS AI system analysis. Primary outcomes focused on changes in metabolic parameters, while secondary outcomes included individual components of metabolic syndrome, inflammation levels, body weight, and adherence to the DS regimen. Data collection involved genetic, metabolic, and clinical profiling, with ethical considerations ensuring participant confidentiality and informed consent.

Inclusion Criteria:

• Age between 40 and 75 years.
• Diagnosed with metabolic syndrome, defined by the presence of at least three of the following criteria:
• Waist circumference > 102 cm (men) or > 88 cm (women).
• Triglycerides ≥ 150 mg/dL.
• HDL cholesterol < 40 mg/dL (men) or < 50 mg/dL (women).
• Blood pressure ≥ 130/85 mm Hg.
• Fasting glucose ≥ 100 mg/dL. • Willingness to provide genetic and metabolic data.

Exclusion Criteria:

• Significant renal, hepatic, or cardiovascular diseases.
• Use of dietary supplements that affect metabolic parameters within the last 3 months.
• Pregnancy or breastfeeding.