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Does adding Dexamethasone to the Periarticular Nerve Group Block in Patients undergoing Total Hip Arthroplasty reduce the dose of ropivacaine?
Hip arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ropivacaine | Active Comparator | Ultrasound-guided PENG block - 20ml 0,2% ropivacaine |
|
| Ropivacaine + Dexamethasone | Active Comparator | Ultrasound-guided PENG block - 10ml 0,2% ropivacaine + 4mg Dexamethasone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine | Drug | Ultrasound-guided PENG block - 20ml 0,2% ropivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to first rescue opioid analgesia | Time after surgery when the patient needs opiate for the first time | 48 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Total Opioid Consumption | Total opiate consumption after surgery | 48 hours after surgery |
| Numerical Rating Scale [range 0:10] | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Malgorzata Reysner, M.D. Ph.D. | Poznań University of Medical Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poznan University of Medical Sciences | Poznan | Poznań | 61-701 | Poland |
Individual participant data will be available following study completion
Following study completion
Eligible researchers
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| ID | Term |
|---|---|
| D015207 | Osteoarthritis, Hip |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Ropivacaine+Dexamethasone | Drug | Ultrasound-guided PENG block - 10ml 0,2% ropivacaine + 4mg Dexamethasone |
|
|
| 4 hours after surgery |
| Numerical Rating Scale [range 0:10] | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) | 8 hours after surgery |
| Numerical Rating Scale [range 0:10] | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) | 12 hours after surgery |
| Numerical Rating Scale [range 0:10] | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) | 24 hours after surgery |
| Numerical Rating Scale [range 0:10] | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) | 48 hours after surgery |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating | 4 hours after surgery |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating | 8 hours after surgery |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating | 12 hours after surgery |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating | 24 hours after surgery |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating | 48 hours after surgery |
| Nerve damage [range 0-4] | Nerve damage assesment will be performed using the nerve damage score (N0- no nerve damage; N1- minor - sensory paresthesia; N2- major -complete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome) | 12 hours after surgery |
| Nerve damage [range 0-4] | Nerve damage assesment will be performed using the nerve damage score (N0- no nerve damage; N1- minor - sensory paresthesia; N2- major -complete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome) | 24 hours after surgery |
| Nerve damage [range 0-4] | Nerve damage assesment will be performed using the nerve damage score (N0- no nerve damage; N1- minor - sensory paresthesia; N2- major -complete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome) | 48 hours after surgery |
| glucose | blood glucose level | 24 hours after surgery |
| glucose | blood glucose level | 48 hours after surgery |
| NLR | neutrophile-to-lymphocyte ratio | 12 hours after surgery |
| NLR | neutrophile-to-lymphocyte ratio | 24 hours after surgery |
| NLR | neutrophile-to-lymphocyte ratio | 48 hours after surgery |
| PLR | platelet-to-lymphocyte ratio | 12 hours after surgery |
| PLR | platelet-to-lymphocyte ratio | 24 hours after surgery |
| PLR | platelet-to-lymphocyte ratio | 48 hours after surgery |
| D012216 |
| Rheumatic Diseases |
| D000588 |
| Amines |