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Gallium-68-DOTATOC binds primarily with high affinity to somatostatin subtype 2 (SSTR2) receptors and these somatostatin receptors are also overexpressed on inflammation cells when activated.
The hypothesis is that the GATED mode on a Gallium-68-DOTATOC cardiac recording would be able to highlight abnormalities that could be correlated with the age of the patients and their cardiovascular risk factors.
People with the selection criteria for the study, coming to the nuclear medicine department in order to benefit from a Gallium-68-DOTATOC PET/CT exam as part of a diagnostic or pre-therapeutic assessment of a neuroendocrine tumor will be offer to participate in the study After sign consent, patients were install in a room to have blood drawn for Troponin Ic, BNP and CRP and after Gallium-68-DOTATOC infusion Gallium-68-DOTATOC PET/CT will be recorded and immediately the cardiac record in Gated mode
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Experimental | Person for whom a 68Ga-DOTATOC PET/CT exam is requested as part of the diagnostic or pre-therapeutic assessment of a neuroendocrine tumor |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac ECG-gated PET imaging will added | Other | Blood sample will be used to measure troponin, BNP and CRP . After 68Ga-DOTATOC PET/CT whole body recording, a cardiac ECG-gated PET imaging will added |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between the captation of radiotracer and the cardiovascular disease | Measurement of myocardial activity | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between the captation of radiotracer and the troponin value | Correlation between the myocardial activity and the troponin value | 1 day |
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Inclusion Criteria:
Persons who have received complete information on the organization of the research and who have signed the informed consent and:
Person for whom a 68Ga-DOTATOC PET/CT exam is requested as part of the diagnostic or pre-therapeutic assessment of a neuroendocrine tumour.
Exclusion Criteria:
Person with
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| VERONIQUE ROCH, MSc | Contact | 03 83 15 42 76 | +33 | v.roch@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| Mathieu PERRIN, MD | CHRU Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Veronique Roch | Recruiting | Vandœuvre-lès-Nancy | 54511 | France |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |