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The study aims to summarize patients with mastocytosis and hypertryptasämia (without underlying mastocytosis or no bone marrow biopsy) in relation to demographic information, clinical progress and treatment courses. Biologic samples are collected from available routine diagnostics (serum, skin tissue, gut mucosa, bone marrow, and others) for further use in experimental research.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mastocytosis | Diagnosed mastocytosis according to WHO criteria | ||
| Hypertryptasemia | Repeated elevated serum tryptase with no underlying mastocytosis or no bone marrow biopsy performed |
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| Measure | Description | Time Frame |
|---|---|---|
| Demographics | In the registry we collect patient's demographic data e.g. age, gender, comorbidities, smoking, preexisting atopic disease and other to look for associations to mast cell diseases. | 2010-2025 |
| Disease progression | Patients will followed up over time to get more insight in disease progression.If there is progression detected (e.g. cutaneous mastocytosis to systemic mastocytosis or ISM to advanced forms) those cases will be carefully looked at to identify triggering factors and biomarkers. | 2010-2025 |
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Inclusion Criteria:
Exclusion Criteria:
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all patients with mastocytosis or hypertryptasemia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Claudia Lang, MD | Contact | +41442551111 | claudia.lang@usz.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Zurich | Recruiting | Zurich | 8091 | Switzerland |
set up multicenter registry, patient data will be anonymous
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| ID | Term |
|---|---|
| D008415 | Mastocytosis |
| D000090362 | Mast Cell Activation Disorders |
| ID | Term |
|---|---|
| D009372 | Neoplasms, Connective Tissue |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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PBMC, skin samples, gut tissue, bone marrow
| D007154 | Immune System Diseases |