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To evaluate the efficacy of modified uterine artery ligation and myometrial compression as a conservative measure in improving the prognosis of the morbidly adherent placenta.
According to the International Federation of Gynecology and Obstetrics (FIGO) guidelines, the principal surgical strategy to prevent excessive bleeding related to placenta accreta syndrome is to leave the placenta in situ and perform a primary peripartum hysterectomy at delivery. A hysterectomy may not be preferred by patients wishing to preserve fertility and is detrimental to multiple aspects of the pelvic floor, bowel, and physical functions.
Surgical principles in placenta accreta syndrome include avoiding disruption of the hypervascular placenta, stepwise devascularization, early and comprehensive blood product transfusion, and judicious use of interventional radiologic techniques such as vascular embolization.
Conservative management describes any approach whereby hysterectomy is avoided
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| O- lreay technique group | Other | Group A: In which 86 patients will have bilateral uterine artery ligations as described by O- lreay technique in addition to standard conservative methods. Briefly, two large vicryl stitches were passed using a large-sized needle below and lateral to the lower edge of the uterine incision angle in an anteroposterior direction and then redirected from back to the front through the avascular window in the posterior leaf of the broad ligament just lateral to the uterine border taking care to avoid injury to bowel posteriorly or bladder/ureter anteriorly. The stitches were tied securely anteriorly |
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| Modified O- lreay technique group | Other | Group B: which will include 86 patients we will do our simplified approach which includes;
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| O, lreay suture | Procedure | bilateral uterine artery ligations as described by O- lreay technique in addition to standard conservative methods. Briefly two large vicryl stitches were passed using a large sized needle below and lateral to the lower edge of the uterine incision angle in anteroposterior direction and then redirected from back to the front through avascular window in the posterior leaf of the broad ligament just lateral to the uterine border taking care to avoid injury to bowel posteriorly or bladder/ureter anteriorly. The stitches were tied securely anteriorly |
| Measure | Description | Time Frame |
|---|---|---|
| Amount of blood loss | The primary outcome for the study is the total volume of blood loss in the intra and postoperative period. | 6 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal morbidity | Coagulopathy, need for massive blood transfusion (> 4 units), length of hospital stay, and visceral injuries ICU admission and post-operative pain. | 24 hours post operatively |
| Maternal mortality |
| Measure | Description | Time Frame |
|---|---|---|
| Gynecological conditions | Gynecological complications as amenorrhea, intrauterine adhesions and niche formation. | 6 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hamada Ali, A. professor | Contact | 0201007240754 | hamadaashry@yahoo.com | |
| nesreen shehata, professor | Contact | 0201024150605 | nesoomar@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beni-Suef University | Recruiting | Cairo | Egypt |
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| ID | Term |
|---|---|
| D010921 | Placenta Accreta |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Patients will be randomized into two groups. One of two intraoperative surgical interventions that will be evolved during the study period:
Group A: In which 86 patients will have bilateral uterine artery ligations as described by the O- lreay technique in addition to standard conservative methods. The stitches were tied securely anteriorly.
Group B: which will include 86 patients we will do our simplified approach which include;
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Randomization will be done by online research randomizer as follows (https://www.randomizer.org/about/ ):
2 Sets of 86 Unique Numbers Per Set Range: From 1 to 172
|
| modified O, lreay suture | Procedure |
|
|
Maternal death
| 24 hours postoperatively |
| D010922 | Placenta Diseases |