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Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticity, the ability of the brain to reorganize itself and form new connections in response to stimuli. A particular class of rTMS, intermittent theta burst TMS (iTBS), is commonly used to modulate cortical excitability and induce plasticity for therapeutic purposes, notably for treatment-resistant depression.
Different iTBS stimulation parameters can be used to induce plasticity. This study will focus on two parameters, namely, the form and duration of the electromagnetic stimulation. The shape of the electromagnetic pulse refers to how the electromagnetic wave is configured over time, while the duration is simply the period during which this electromagnetic pulse remains active. These parameters are expected to influence the effectiveness of iTBS in modulating cortical activity but remain little studied.
The main aim of this study will be to compare the effectiveness of different stimulation parameters in the induction of plasticity, which will then make it possible to improve the rTMS protocols used for treatment-resistant depression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intermittent theta burst stimulation (iTBS) | Experimental | All participants will understand 3 different iTBS protocols, each separated by one week. The order of the iTBS protocols will be randomized. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Monophasic iTBS | Device | iTBS protocol with monophasic-shaped pulses. iTBS parameters:
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| Measure | Description | Time Frame |
|---|---|---|
| TMS derived measure of cortical plasticity | Change in Peak-to-peak motor evoked potential (MEP) amplitude induced by the administration of the test stimulus (stimulation intensity required to produce an MEP of 1 millivolt, approximately 120% of rMT) after iTBS | Pre-iTBS, Every 5 minutes post iTBS intervention up to 60 minutes post intervention. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Samantha Cote, Ph.D. | Contact | 819-346-1110 | 70184 | Samantha.cote@usherbrooke.ca |
| Jean-Francois Lepage, Ph.D. | Contact | 819-346-1110 | 71020 | jean-francois.lepage@usherbrooke.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de recherche du Centre hospitalier universitaire de Sherbrook | Recruiting | Sherbrooke | Quebec | J1H 5H3 | Canada |
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Repeated Measure Design
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| Biphasic iTBS | Device | iTBS protocol with biphasic-shaped pulses. iTBS parameters:
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| Monophasic-Long iTBS | Device | iTBS protocol with long monophasic-shaped pulses. iTBS parameters:
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