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| ID | Type | Description | Link |
|---|---|---|---|
| 0000-0002-5945-7764 | Other Identifier | 0000-0002-5945-7764 |
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The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are:
Participants will:
Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms.
Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genetic polymorphism | Genetic | The biological significance of HTR2A and DRD3 in bruxism remains unclear as molecular analyses, including genetic association studies, have not explored the mRNA expression of genes implicated in bruxism. This study aims to evaluate the influence of genetic polymorphisms affecting DRD3 (rs6280) and HTR2A (rs6313) on bruxism to identify potentially associated genotypes. Additionally, it aims to investigate the expression of HTR2A and DRD3 to elucidate their biological significance in bruxism. |
| Measure | Description | Time Frame |
|---|---|---|
| PCR-RFLP Analysis | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 170 participants will be included in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yosra Gassara | Contact | 216-587-5455 | +216 55374741 | chouchengassarayosra@gmail.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32367059 | Result | Wieckiewicz M, Bogunia-Kubik K, Mazur G, Danel D, Smardz J, Wojakowska A, Poreba R, Dratwa M, Chaszczewska-Markowska M, Winocur E, Emodi-Perlman A, Martynowicz H. Genetic basis of sleep bruxism and sleep apnea-response to a medical puzzle. Sci Rep. 2020 May 4;10(1):7497. doi: 10.1038/s41598-020-64615-y. | |
| 42237294 | Derived |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D002012 | Bruxism |
| D020186 | Sleep Bruxism |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D006184 | Habits |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D011110 | Polymorphism, Genetic |
| ID | Term |
|---|---|
| D014644 | Genetic Variation |
| D055614 | Genetic Phenomena |
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Blood samples
| Gassara Y, Foddha H, Chouchene S, Nasri S, Kallala R, Haj Khelil A, Hassin M, Ben Abdennebi H, Harzallah B. Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism. BMC Oral Health. 2026 Jun 3. doi: 10.1186/s12903-026-08633-8. Online ahead of print. |
| D020447 |
| Parasomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |