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The aim of the present study is:
To assess the hemostatic effect of chitosan-based dressing, Ankaferd and Tranexamic acid after extraction in children with end stage liver diseases where the:
• Primary objective: is to evaluate which of the previous materials will be the most effective as a hemostatic agent
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 sterile gauze with chitosan | Experimental | Chitosan-based dressing gauze after extraction in patients with end stage liver disease |
|
| group 2 sterile gauze with ankaferd blood stopper | Experimental | ankaferd blood stopper dressing gauze after extraction in patients with end stage liver disease |
|
| group 3 sterile gauze with tranexamic acid | Active Comparator | tranexamic acid dressing gauze after extraction in patients with end stage liver disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tranexamic acid | Drug | Application of sterile gauze after extraction for hemostasis |
|
| Measure | Description | Time Frame |
|---|---|---|
| To assess the hemostatic effect of chitosan-based dressing, Ankaferd and Tranexamic acid after extraction in children with end stage liver diseases | evaluation of the previous materials which will be the most effective as a hemostatic agent by measuring blood loss after dental extraction after 30 minutes by the weight difference between the gauze preoperatively and postoperatively using fine electronic measurement weight device | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| pain score assessment | Pain scores will be assessed using Visual Analog Scale from 0 to 10 pain score for seven days following extraction where 0 is no pain and 10 is maximum pain | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| noha S Kabil | British University In Egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| British University in Egypt | Cairo | Egypt |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| C539751 | ankaferd blood stopper |
| D048271 | Chitosan |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Ankaferd Blood Stopper | Drug | Application of sterile gauze after extraction for hemostasis |
|
| Chitosan | Drug | Application of sterile gauze after extraction for hemostasis |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D002686 |
| Chitin |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |