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Patients with hyperthyroidism or hypothyroidism are often combined with atrial fibrillation, but after the stabilization of thyroid hormone levels after treatment, the patients' atrial fibrillation still persists. Radiofrequency ablation of the atrial fibrillation as one of the treatment options for atrial fibrillation has been widely used in the clinic, and has significant efficacy in maintaining sinus rhythm, improving cardiac function, and improving the prognosis of patients. However, there is a lack of clinical monitoring data on radiofrequency ablation of atrial fibrillation in patients who have combined thyroid dysfunction and have stabilized their thyroid hormone levels after treatment.
In patients recommended by guidelines for atrial catheter radiofrequency ablation of atrial fibrillation, catheter radiofrequency ablation was performed after exclusion of contraindications, and was observed and compared between patients with comorbid pre-existing thyroid hormone disorders and patients without comorbid atrial fibrillation after radiofrequency ablation:1: time to sexual rhythm maintenance: incidence of cardiac-related complications and incidence of noncardiac-related complications within 3 months and 1 year,2: walking distance on a six-minute walk test within 3 months,1 year, comparison of percent left ventricular ejection fraction, and comparison of left ventricular diastolic diameter at the time 3 months,1 year,.To comprehensively assess the efficacy and safety of catheterized radiofrequency ablation of atrial fibrillation in patients with comorbidities of prior thyroid hormone disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Combined Thyroid Dysfunction | Atrial catheter radiofrequency ablation for atrial fibrillation combined with patients requiring prior thyroid hormone abnormalities |
| |
| Uncomplicated thyroid dysfunction | Atrial catheter radiofrequency ablation for atrial fibrillation in patients with uncomplicated need for prior thyroid hormone abnormalities |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Catheter Ablation | Procedure | catheter radiofrequency ablation therapy for atrial fibrillation involves the use of ablative energy to destroy the cardiomyocytes at the opening of the pulmonary veins, which blocks the electrical conduction pathway between the pulmonary veins and the left atrium, so that atrial fibrillation no longer occurs. |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation | Inability to maintain sinus rhythm, recurrent atrial fibrillation or atrial flutter | 3 month and 1year after cardiac radiofrequency ablation |
| Postoperative heart-related complications | Cardiac perforation/cardiac tamponade Coronary artery stenosis/occlusion Pericarditis Atrial stiffness syndrome Coronary artery air embolism Pseudoaneurysm Severe pulmonary stenosis | 3 month and 1year after cardiac radiofrequency ablation |
| Non-Cardiac Related Complications | Neurological Complications Asymptomatic cerebral embolism TIA Perioperative stroke Permanent phrenic nerve injury Digestive Complications Esophageal Injury Gastric Hyperdynamics Atrioesophageal Fistula Vascular Complications Hematoma Arteriovenous fistula Pseudoaneurysm Severe pulmonary stenosis | 3 month and 1year after cardiac radiofrequency ablation |
| Measure | Description | Time Frame |
|---|---|---|
| 6-minute walk test | Left atrial diastolic diameter | 3 month and 1year after cardiac radiofrequency ablation |
| Left Atrial Internal Diameter | Left atrial anteroposterior and superior-inferior diameters |
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid hormone levels | hyperthyroidism Hypothyroidism A change in thyroid hormone status from stable to unstable. | 3 month and 1year after cardiac radiofrequency ablation |
Inclusion Criteria:
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation （Class I Recommendation）
Exclusion Criteria:
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation Class I Recommendation With Coexisting Contraindications
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Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation Class I Recommendation Without Concurrent Contraindication
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Medicine Department of Second Affiliated Hospital of Jiaxing University | Jiaxing | Zhejiang | 314000 | China |
no Plan to Share IPD
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D006980 | Hyperthyroidism |
| D007037 | Hypothyroidism |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D017115 | Catheter Ablation |
| ID | Term |
|---|---|
| D000078703 | Radiofrequency Ablation |
| D000078702 | Radiofrequency Therapy |
| D013812 | Therapeutics |
| D055011 | Ablation Techniques |
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| 3 month and 1year after cardiac radiofrequency ablation |
| LVEF% | Per-beat output as a percentage of ventricular end-diastolic volume (cardiac preload) | 3 month and 1year after cardiac radiofrequency ablation |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D013514 |
| Surgical Procedures, Operative |