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The investigators conducted a muti-centres randomized controlled clinical trial to explore the effect of preservation of inferior pulmonary ligment compared with dissection.
Dissection of the inferior pulmonary ligament (IPL) has been a common practice in upper lobectomy to facilitate the expansion of the remaining lung, reduce dead space after resection, and minimize complications such as pleural effusion and pulmonary infection. However, studies have found that IPL dissection does not improve patient outcomes. On the contrary, releasing the restriction may lead to excessive movement of the remaining lobes, resulting in significant changes in bronchial angles and lung volume, which can worsen pulmonary function and increase postoperative symptoms. Most existing studies are retrospective, providing relatively low-level evidence. Moreover, previous research has primarily focused on radiographic outcomes and pulmonary function tests results, while the effect on patients' symptom burden has been largely overlooked. From the patient's perspective, symptom burden might be more significant, reflecting the clinical value of changes in radiographic and functional indices. In this study, the investigators applied patient-reported outcomes to measure symptoms. Combined with pulmonary function results and radiological outcomes, the investigators compared the clinical value of preserving versus dissecting the IPL in upper lobectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preservation group | Experimental | In the preservation group, the IPL was untouched |
|
| Dissection group | No Intervention | In the dissection group, the IPL was commonly dissected until the inferior pulmonary vein was exposed |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preserving IPL during surgery | Procedure | IPL was preserved during surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cough score postoperation | The investigators used PSA-LUNG questionnaire to assess patients symptom burden after surgery. Changing of cough score during 1 month postoperation was chosen as the primary outcome. | up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Other Symptom burden postoperation PSA-LUNG questionnaire | Using PSA-LUNG questionnaire, the investigators assessed shortness of breath, pain, sleeplessness, annoy, and fatigue after surgery. | up to 3 months |
| Radiological outcome |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guibin Qiao, MD | Contact | 13602749153 | guibinqiao@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Guibin Qiao, MD | Guangdong Province People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| General Hospital of Southern Theater Command of the Chinese People's Liberation Army | Guangzhou | Guangdong | 510080 | China |
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Changing of bronchial angels measured with chest x-ray examination or chest CT.
| Day 1 after surgery; 1 month after discharge; 3 months after discharge |
| Radiological outcome | dead spece rate measured with chest x-ray examination or chest CT. | Day 1 after surgery; 1 month after discharge; 3 months after discharge |
| Radiological outcome | degree of lung collapse measured with chest x-ray examination or chest CT. | Day 1 after surgery; 1 month after discharge; 3 months after discharge |
| Guangdong Provincial People's Hospital | Guangzhou | Guangdong | 510080 | China |
|
| The Affiliated Panyu Central Hospital of Guangzhou Medical University | Guangzhou | Guangdong | 510080 | China |
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| The First Affiliated Hospital of Guangdong Pharmaceutical University | Guangzhou | Guangdong | 510080 | China |
|
| Shantou University Medical College | Shantou | Guangdong | 515041 | China |
|