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The aim of this study was to compare the effectiveness and safety of selective serotonin reuptake inhibitors (dapoxetine) and hyaluronic acid gel injection in the glans penis for lifelong premature.
Over the past 30 years, the common knowledge of Premature ejaculation (PE) has advanced strikingly. PE is a very common and upsetting sexual male dysfunction. It is disturbing for both partners affecting their sexual experience, reducing their quality of life up to sexual abstinence, causing lack of self-confidence and even depression. It has a prevalence of a variable range, yet it is thought that one third of all males might complain of PE at a certain point throughout their lives and the incidence is rising.
Many treatment modalities have been currently used for PE varying from behavioral therapy to medical treatment and finally surgical therapy. Methods of behavioral therapy are: Squeeze technique and Start/stop technique. Pharmacological therapies include: nonselective and selective SSRIs, topical therapy with anesthetics, PDE5 inhibitors, opioid agonists and others. As for surgical modalities for PE there are several techniques including: glans augmentation, frenectomy, dorsal selective neurectomy, pulsed radiofrequency neuromodulation, removal of foreskin remnants and varicocelectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Selective serotonin re-uptake inhibitor | Active Comparator | Patients received selective serotonin re-uptake inhibitor (SSRI) as medical treatment for treatment of premature ejaculate. |
|
| Hyaluronic acid | Experimental | Patients received hyaluronic acid gel injection in the glans penis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Selective serotonin re-uptake inhibitor | Drug | Patients received selective serotonin re-uptake inhibitor as medical treatment for treatment of premature ejaculate. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intravaginal ejaculation latency time (IELT) | Intravaginal ejaculation latency time (IELT) is time from initiating sexual activity to ejaculation and used for diagnosis of Long-term premature ejaculation. It was assessed at the 1st, 3rd, and 6th months following treatment. | 6 months following treatment |
| Measure | Description | Time Frame |
|---|---|---|
| International index of erectile function-5 (IIEF-5) | International index of erectile function-5 (IIEF-5) was used for diagnosis of Long-term premature ejaculation and classified into five categories: no (score 22-25), mild (17-21), mild to moderate (12-16), moderate (8-11), and severe (5-7). It was assessed at the 1st, 3rd, and 6th months following treatment. | 6 months following treatment |
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Inclusion Criteria:
Exclusion Criteria:
Males suffering from lifelong premature ejaculation not responding to the behavioral therapy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New Valley University | New Valley | New Valley Governorate | 72511 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| Hyaluronic acid | Drug | Patients received injection of glans penis with hyaluronic acid |
|
| Index of premature ejaculation (IPE) | Index of premature ejaculation (IPE) is a 10 item self-administered questionnaire designed to evaluate sexual satisfaction, control and distress in men with premature ejaculation. It diagnosis premature ejaculation (PE) (≤8), possible PE (9 or 10), and no PE (≥11).It was assessed at the 1st, 3rd, and 6th months following treatment. | 6 months following treatment |
| Patient satisfaction | Degree of patient satisfaction was assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied). Degree of patient satisfaction was assessed at the 1st, 3rd, and 6th months following treatment. | 6 months following treatment |
| Incidence of side effects | Side effects such as nausea, dizziness, headache, dry mouth, pain at site of injection, ecchymosis, and bullae formation at site of injection were recorded. | 6 months following treatment |
| ID | Term |
|---|---|
| D017367 | Selective Serotonin Reuptake Inhibitors |
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D014179 | Neurotransmitter Uptake Inhibitors |
| D049990 | Membrane Transport Modulators |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D018377 | Neurotransmitter Agents |
| D018490 | Serotonin Agents |
| D045505 | Physiological Effects of Drugs |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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