Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients

Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients

Introduction:

A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).

Methodology:

A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.

Inclusion Criteria:

• Grave's Disease
• either starting or about to start anti-thyroid medication (ATD)

Exclusion Criteria:

• Chronic granulomatous disease
• hypercalcemia
• poor renal function (eGFR < 45 ml/min)
• the presence of malignant disease