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Our study aims to delve into the effects of shifting the focal point of blue light from video or text displayed on a terminal screen forward on the axial length of the eye, ocular blood flow, visual fatigue, and visual function, that is, its relationship with Video Display Terminal (VDT) syndrome and myopia. By examining the decoding ability of the adult subjects' retina to the clarity of the signal, we will attempt to develop a novel, non-invasive strategy to curb the elongation of the eyeball associated with myopia. Concurrently, we will also focus on the pathophysiological mechanisms underlying VDT syndrome and explore its potential link to the progression of myopia, providing new scientific evidence for the prevention and treatment of this ocular condition. This research is expected to provide robust support for addressing the global issue of myopia and the health challenges posed by VDT syndrome. Ultimately, by integrating global eye health issues with the challenges brought about by VDT syndrome, we will propose intervention and prevention strategies, offering new insights for the advancement of ophthalmology and public health sectors, thereby promoting visual acuity and ocular health for the population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blue Light 0D Defocus Group | Experimental | This is the group that performs visual evoked tasks using videos and texts that are not defocused in the blue channel. In this group, the impact of standard video modes on the axial length of the eye, refractive fatigue, and visual function is assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow. |
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| Blue Light 1D Defocus Group | Experimental | Group using blue channel defocused 1D videos and texts for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts processed with 1D blue channel. The impact of standard video mode on axial length of the eye, refractive labor, and visual function will be assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow. |
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| Blue Light 2D Defocus Group | Experimental | The group uses blue channel defocused 2D videos and texts for visual evoked tasks. Participants will undergo a 50-minute visual evoked task using videos and texts processed with the 2D blue channel. The effects of standard video mode on the eye's axial length, refractive labor, and visual function are assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow. |
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| Blue Light 1D Defocus with Partial Filtration Group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blue light defocus and blue light filtering | Behavioral | Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order. |
| Measure | Description | Time Frame |
|---|---|---|
| Ocular Fundus Blood Flow | The study measured the sub foveal choroidal thickness, superficial vessel complex (SVC) density, and deep vessel complex (DVC) density, analyzing changes in retinal blood flow under the two modes. | The total duration of the visual task is 50 minutes. Retinal blood flow is measured for each subject at 0 minutes, 25 minutes, and 50 minutes during the visual task, resulting in a |
| Measure | Description | Time Frame |
|---|---|---|
| Visual fatigue | The visual fatigue questionnaire utilized in this study consists of a self-report survey with a total of 19 items. It is designed to comprehensively assess the severity of visual fatigue symptoms, with a scoring system ranging from 1 to 7. Higher scores indicate more severe symptoms, encompassing three primary domains: ocular symptoms, visual discomfort, and psychological aspects triggered by visual fatigue. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tongren Hospitol, Capital Medical University | Beijing | Beijing Municipality | 100730 | China |
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| ID | Term |
|---|---|
| D001248 | Asthenopia |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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This study is designed with a total of four groups, where participants will sequentially and randomly undergo all the intervention procedures.
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The group uses videos and texts processed with the blue channel 1D defocus and 30% blue light filtering for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts that have been processed with the 1D blue channel and partially filtered for blue light. The impact of the standard video mode on the eye's axial length, refractive labor, and visual function is evaluated, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow. |
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| Each participant will complete the visual fatigue questionnaire, followed immediately by a VEP task, and then re-assess visual fatigue immediately afterward. This sequence will occur twice per group, totaling eight assessments per participant. |
| Measurement of Accommodative Sensitivity with Flip-Chart Post-VEP Tasks | This clinical study involves the assessment of accommodative sensitivity for both monocular and binocular vision using a flip-chart immediately following each visual evoked potential (VEP) task. The measurement will quantify the number of optotypes correctly identified within one minute, indicative of the subject's accommodative capacity. | Each participant will have five measurements: a baseline, and four post-VEP tasks, with immediate flipchart tests after each task. |
| Blink Frequency | Use electronic devices to record the number of clicks within 3 minutes and calculate the frequency. | Blink frequency 3 minutes after the start of each visual evoked task and 3 minutes before the end. |
| Reading efficiency | The number pairs were read in the first and last 5 minutes of the visual evoked task, and the number of number pairs read per minute was counted. | The test was recorded 5 minutes after the start and 10 minutes before the end. |
| AC/A Ratio Measurement Post-VEP Tasks | This study involves the measurement of the AC/A ratio, which is a critical parameter in binocular vision assessment, reflecting the relationship between accommodation (focus adjustment) and convergence (ocular alignment). The AC/A ratio will be determined using the prism bar technique, which involve adding lenses to stimulate accommodation and measuring the resulting changes in convergence. | Each participant will undergo five AC/A ratio measurements: at baseline and immediately after each of four VEP tasks. |