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| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies (PID).
Neuraxial anaesthesia (epidural or intradural) is often used to alleviate pain during labour and childbirth. Although extremely efficient and safe, rare but serious infectious complications such as epidural abscess or meningitis can occur afterwards.
Patients with PID tend to have a greater risk of infectious complications than the general population. With the progress of medical care in those pathologies, female patients are now giving birth more often. The use of neuraxial anaesthesia and the associated infectious complications have never been studied in this population.
The investigators intend to review the medical records of PID patients who gave birth in an APHP hospital in the last 10 years to evaluate the use of neuraxial anesthesia and the frequency of infectious complications associated with neuraxial anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | CEREDIH (centre de reference des deficits immunitaires héréditaires) cohort Female patients, alive and > 18 years old, registered at the CEREDIH who gave birth in an APHP maternity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non applicable | Other | Non applicable (data collection) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who develop a local or systemic infection, such as an epidural abscess or meningitis, within 28 days after receiving neuraxial anesthesia during delivery | Occurrence of a local or systemic infection post-neuraxial anesthesia within 28 days after delivery / Infectious complication after obstetrical neuraxial anesthesia / Epidural abscess or meningitis after neuraxial anesthesia | 28 days post-partum |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of Alternative Pain Relief Methods Utilized Due to Contraindications Linked to Primary Immunodeficiency | Use of an alternate method for pain-relief during childbirth / Use of another method of pain relief due to a contraindication linked to primary immunodeficiency | During labour |
| Rate of Antibioprophylaxis Administration During Neuraxial Anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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Female eligible patients from the CEREDIH cohort will be included.
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| Name | Affiliation | Role |
|---|---|---|
| Caroline Charlier-Woerther | APHP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Infectiology mobile team - Department of Infectious and Tropical Diseases | Paris | Île-de-France Region | 75014 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40226770 | Result | Beloeuvre A, Anselem O, Tazi A, Keita-Meyer H, Mahlaoui N, Charlier C. Anesthetic management of women with primary immunodeficiencies in the obstetric setting: A French cohort study (ANEU-DIP). J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100433. doi: 10.1016/j.jacig.2025.100433. eCollection 2025 May. |
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| ID | Term |
|---|---|
| D020802 | Epidural Abscess |
| D008581 | Meningitis |
| ID | Term |
|---|---|
| D020819 | Perimeningeal Infections |
| D002494 | Central Nervous System Infections |
| D007239 | Infections |
| D000038 | Abscess |
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Use of a antibioprophylaxis when performing neuraxial anesthesia |
| up to 24 hours after birth |
| Number of cases where maternity anesthetists identify contraindications to performing neuraxial anesthesia in patients with primary immunodeficiency | Possible occurrence of contraindications identified by the maternity anesthetist to the performance of neuraxial anesthesia linked to primary immunodeficiency | During labour |
| D013492 |
| Suppuration |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D000090862 | Neuroinflammatory Diseases |