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Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI). CT imaging can potentially differentiate between reversible and irreversible ischaemic damage of the bowel. This moment is pivotal in selecting the treatment strategy for AMI - in the absence of irreversible damage; reperfusion therapy can preserve intestinal viability, thereby avoiding the need for bowel resection. The present study tests the hypothesis that combining several symptoms may enhance the diagnostic performance of CT scanning in detecting salvageable bowel in patients with AMI. This study is an ancillary component of the AMESI study (Clinical Trials: NCT05218863) - a prospective, multicentre observational study aimed at identifying the incidence and describing the outcomes of acute mesenteric ischemia (AMI) in adult hospitalized patients. The ultimate purpose of the present study is to create a computed tomography-based radiological score for the assessment of bowel viability in patients with AMI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Controls | Patients included in the AMESI study as suspected AMI | ||
| AMI patients with salvageable bowel | Patients included in the AMESI study with confirmed AMI, who did not undergo bowel resection Patients with one of the following:
| ||
| AMI patients with non-salvageable bowel | Patients included in the AMESI study with confirmed AMI who (one of the following):
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| Measure | Description | Time Frame |
|---|---|---|
| Frequency rate | Frequency rate of common radiological signs in AMI patients with and without salvageable bowel. | up to one month |
| Measure | Description | Time Frame |
|---|---|---|
| Performance of the radiological score | Performance of the radiological score in patients with different types of AMI. | up to one month |
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Inclusion Criteria:
Exclusion Criteria:
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This is a substudy of the AMESI study - "Incidence, Diagnosis, Management, and Outcome of Acute Mesenteric Ischaemia: A Prospective, Multicentre Observational Study." (Clinical Trials: NCT05218863) As of the end of August 2023, a total of 705 patients from 32 study sites worldwide have been enrolled, with 418 of them having confirmed cases of AMI. For patients with confirmed AMI, comprehensive data collection concerning diagnostics, management, and long-term outcomes has been completed
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joel Starkopf | Contact | 53318400 | 372 | joel.starkopf@ut.ee |
| Kätlin Eiche | Contact | Katlin.Eiche@ut.ee |
| Name | Affiliation | Role |
|---|---|---|
| Joel Starkopf | University of Tartu, Department of Anaesthesiology and Intensive Care | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tartu University Hospital | Recruiting | Tartu | 50408 | Estonia |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jan 3, 2024 | May 22, 2024 | Prot_000.pdf |
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