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Single-center, non-profit, observational, retrospective study of collection of clinical and amnestic data and images to create, implement and develop a pilot model of an integrated virtual platform.
The project we propose is a study whose objective was to develop an artificial intelligence program integrated into a web-based platform for the optimization of the performance of lung cancer screening for the diagnosis of lung nodules and risk stratification in subjects exposed to environmental carcinogens and/or cigarette smoke.
Inclusion criteria:
Age > 50; smokers for at least 20 pack-years (20 cigarillos a day for 20 years) or former heavy smokers if they quit less than 15 years ago; and/or previous professional exposure to asbestos; absence of lung cancer symptoms; who performed lung cancer screening after the year 2000 upon approval of the study by the relevant EC.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subjects enrolled in lung cancer screening | Actual Smokers or formers smoker; Age > 50 years. |
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| Measure | Description | Time Frame |
|---|---|---|
| AIM 1 Pilot deep learning model | Development and fine-tuning of a pilot deep learning model for automatic detection and diagnosis of screen-detected nodules for risk stratification in subjects with asbestos exposure as part of a lung cancer screening program in high-risk subjects for exposure to asbestos and smoking on retrospective data. | from enrollment to the end of treatment at 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| AIM 2 Clinical database | Development of an integrated system between the clinical database and several existing imaging volumetric software and risk models for the creation of a pilot platform in order to optimize the organizational management of lung cancer screening. | from enrollment to the end of treatment at 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Age > 50 years; smokers for at least 20 pack-years (20 cigarettes a day for 20 years) or former heavy smokers if they quit less than 15 years ago; and/or previous professional exposure to asbestos.
All subjects were enrolled in lung cancer screening program.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS San Raffaele Scientific Institute | Milan | 20132 | Italy |
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