comparing the clinical efficacy of intra-articular injection of platelet lysate (PL), versus Hyaluronic Acid after arthrocentesis in the management of patients with anterior disc displacement with reduction.

Inclusion Criteria:

• Patients that will be diagnosed with anterior disc displacement with reduction (ADDWR) both clinically and through magnetic resonance imaging scan (MRI).
• Patients who will not respond to a previous conservative therapy.
• Patients with pain in temporomandibular joints.
• Patients with normal or limitation in mouth opening.
• Patients with clicking sound.

Exclusion Criteria:

• Patients with previous invasive TMJ surgical procedures.
• Patients with inflammatory or connective tissue diseases.
• Patients with neurologic disorders.
• Patients with history of bony or fibrous adhesion.
• Patients having gross mechanical restrictions and condylar fractures.
• Patients with psychological problems.
• Patients receiving anti-coagulation treatment, non-steroidal anti-inflammatory drugs within 48 hours pre-operatively, corticosteroid injection at the treatment site within one month or systemic use of corticosteroids within 2 weeks.