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| Name | Class |
|---|---|
| Lacer S.A. | INDUSTRY |
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The objective of this project was to compare the immediate antimicrobial effect and in situ substantivity of a new 0.20% chlorhexidine (CHX) gel and cymenol with the current CHX gel formulation on dental plaque biofilm and salivary flora up to 7 hours after a single application.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.20% CHX gel | Active Comparator | Participants underwent a single application of the 0.20% CHX gel. Samples were collected in basal conditions (i.e., before application) and at 5 minutes, 1 hour, 3 hours, 5 hours and 7 hours after application. |
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| 0.20% CHX and Cymenol gel | Experimental | Participants underwent a single application of the 0.20% CHX + Cymenol gel. Samples were collected in basal conditions (i.e., before application) and at 5 minutes, 1 hour, 3 hours, 5 hours and 7 hours after application. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.20% CHX gel on saliva | Drug | In vivo application of a gel on the vestibular and palatal/lingual gingival mucosa of both arches at minute 0 for posterior saliva collection at different time-points. |
| Measure | Description | Time Frame |
|---|---|---|
| Intragel bacterial viability: baseline vs 5 minutes | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: baseline vs 5 minutes | Baseline, 5 minutes |
| Intragel bacterial viability: baseline vs 1 hour | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: baseline vs 1 hour | Baseline, 1 hour |
| Intragel bacterial viability: baseline vs 3 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: baseline vs 3 hours | Baseline, 3 hours |
| Intragel bacterial viability: baseline vs 5 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: baseline vs 5 hours | Baseline, 5 hours |
| Intragel bacterial viability: baseline vs 7 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: baseline vs 7 hours | Baseline, 7 hours |
| Intragel bacterial viability: 5 minutes vs 1 hour | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: 5 minutes vs 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Inmaculada Tomás, Prof | University of Santiago de Compostela, Spain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Santiago de Compostela | Santiago de Compostela | A Coruña | 15782 | Spain |
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| 0.20% CHX and Cymenol gel on saliva | Drug | In vivo application of a gel on the vestibular and palatal/lingual gingival mucosa of both arches at minute 0 for posterior saliva collection at different time-points. |
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| 0.20% CHX gel on oral biofilm | Drug | Ex vivo application of a gel on the glass disks of the removable intraoral appliance at minute 0 for subsequent one-by-one disk removal from the device at different time-points. |
|
| 0.20% CHX and Cymenol gel on oral biofilm | Drug | Ex vivo application of a gel on the glass disks of the removable intraoral appliance at minute 0 for subsequent one-by-one disk removal from the device at different time-points. |
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| 5 minutes, 1 hour |
| Intragel bacterial viability: 5 minutes vs 3 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: 5 minutes vs 3 hours | 5 minutes, 3 hours |
| Intragel bacterial viability: 5 minutes vs 5 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: 5 minutes vs 5 hours | 5 minutes, 5 hours |
| Intragel bacterial viability: 5 minutes vs 7 hours | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) with either 0.20% CHX gel or 0.20% CHX and cymenol gel: 5 minutes vs 7 hours | 5 minutes, 7 hours |
| Intergel bacterial viability at baseline: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) at baseline: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | Baseline |
| Intergel bacterial viability after 5 min: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) after 5 minutes: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | 5 minutes |
| Intergel bacterial viability after 1 hour: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) after 1 hour: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | 1 hour |
| Intergel bacterial viability after 3 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) after 3 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | 3 hours |
| Intergel bacterial viability after 5 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) after 5 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | 5 hours |
| Intergel bacterial viability after 7 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel | Percentage of bacterial viability (Ratio of viable bacteria to total bacteria -viable + non-viable- multiplied by 100) after 7 hours: 0.20% CHX gel vs 0.20% CHX and cymenol gel. | 7 hours |