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Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training [HIIT] and moderate intensity continuous training [MICT]) is scarce.
Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity interval training (HIIT) | Active Comparator | The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. |
|
| Moderate intensity continuous training (MICT) | Active Comparator | The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Type of Exercise | Other | The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak. |
| Measure | Description | Time Frame |
|---|---|---|
| HF parameter | High frequency domain of the HRV | 5-minutes high resolution ECG recording before and after an exercise session |
| Measure | Description | Time Frame |
|---|---|---|
| LF parameter | Low frequency domain of the HRV | 5-minutes high resolution ECG recording before and after an exercise session |
| SDNN | Standard deviation of NN intervals |
| Measure | Description | Time Frame |
|---|---|---|
| Non-linear methods | SD1, SD2 | 5-minutes high resolution ECG recording before and after an exercise session |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marko Novaković, MD, PhD | Contact | 0038615228032 | marko.novakovic@kclj.si |
| Name | Affiliation | Role |
|---|---|---|
| Marko Novaković, MD, PhD | University Medical Centre Ljubljana | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Centre Ljubljana | Recruiting | Ljubljana | 1000 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20548976 | Background | Routledge FS, Campbell TS, McFetridge-Durdle JA, Bacon SL. Improvements in heart rate variability with exercise therapy. Can J Cardiol. 2010 Jun-Jul;26(6):303-12. doi: 10.1016/s0828-282x(10)70395-0. | |
| 38578755 | Background | El-Malahi O, Mohajeri D, Mincu R, Bauerle A, Rothenaicher K, Knuschke R, Rammos C, Rassaf T, Lortz J. Beneficial impacts of physical activity on heart rate variability: A systematic review and meta-analysis. PLoS One. 2024 Apr 5;19(4):e0299793. doi: 10.1371/journal.pone.0299793. eCollection 2024. |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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Each patient will have a bout of HIIT during one session and a bout of MICT during another session performed in a random order.
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HRV parameters analysis will be blinded regarding the exercise training modality.
|
| 5-minutes high resolution ECG recording before and after an exercise session |
| RMSSD | Root mean square of successive RR interval differences | 5-minutes high resolution ECG recording before and after an exercise session |
| pNN50 | Percentage of successive RR intervals that differ by more than 50 ms | 5-minutes high resolution ECG recording before and after an exercise session |
| 34789148 | Background | Grassler B, Thielmann B, Bockelmann I, Hokelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. 2021 Nov 17;18(1):24. doi: 10.1186/s11556-021-00278-6. |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |