Impact of Yoga on Cognitive Function

A Pilot and Feasibility Study of a Yoga Intervention in Heart Failure Patients With Mild Cognitive Impairment

Mild cognitive impairment is highly prevalent in patients with heart failure and results in poor well-being and quality of life. While yoga has proven effective in promoting cognitive health in older adults through its gentle movements, controlled breathing, and meditation, its effects on patients with heart failure remain unknown. Therefore, this feasibility and pilot study plans to deliver a 12-week yoga intervention and test its effects on cognitive function in patients with heart failure and mild cognitive impairment.

A prospective, 2-arm comparative feasibility design will be used. The investigators will enroll 24 patients with a confirmed heart failure diagnosis with mild cognitive impairment. Patients will be randomized equally into yoga intervention or control group. Patients in the yoga intervention group will receive a 60-minute yoga session twice per week for 12-week. Survey, cognitive function data, MRI scans, and blood samples will be collected at baseline and at 3 months (after completion of yoga intervention).

Inclusion Criteria:

• Aged 55 years and older
• Confirmed heart failure diagnosis with mild cognitive impairment
• New York Heart Association functional class II-IV

Exclusion Criteria:

• Co-existing neurological disorders, traumatic brain injury, psychiatric disorders, or terminal illnesses
• Have implanted defibrillator, left ventricular assist device placement or cardiac transplant
• Have any other implanted metals that interfere with the MRI magnetic field for patient safety
• Substance abuse
• Pregnant
• Unable to perform yoga due to physical limitations or severity of illness