Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.

The study is a 6-wk randomized, controlled, and parallel arm clinical trial. Participants will be randomized to consume either lean grain-fed beef, lean grass-fed beef, or plant-based meat for 6 weeks. Outcomes assessed will include metabolic, inflammatory, and gut microbiome markers.

Inclusion Criteria:

• Age: 18-45 years of age
• BMI: 18-35 kg/m2
• Willingness to consume study foods.
• Willing to comply with study protocol.
• Consistent diet and activity patterns for 4 weeks
• Weight stable (≤5 kg change over the last 3 months)
• Non-smoker >1 year or more

Exclusion Criteria:

• Allergies to foods provided in the study
• Diabetes
• Gastrointestinal disease and/or bariatric surgery
• Uncontrolled hypertension and blood pressure ≥ 180/110
• Illicit drug use
• Recent consumption of antibiotics or probiotics
• Recent start of medications that affect metabolism or appetite.
• Recent blood donation
• Drug therapy for coronary artery disease, peripheral artery disease, congestive - heart failure, or dyslipidemia
• Pregnant or lactating individuals
• Taste or smell disorders
• High consumers of red meat or plant-based meat (≥ 4 times/week)