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| ID | Type | Description | Link |
|---|---|---|---|
| Si 359/2024 | Other Identifier | Siriraj Institutional Review Board |
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The objective of this study is to examine the predictive capability of the Obstetric comorbidity index in the identification of severe maternal morbidity associated with postpartum hemorrhage in patients undergoing cesarean delivery.
The prospectively predictive maternal morbidity is imperative to enhance maternal outcomes. There has been development of the obstetric comorbidity index (OBCMI) by Bateman et al. in 2013 and performed with superior performance characteristics relative to general comorbidity measures in an obstetric population. The score has been a growing recognition of the necessity for specialized risk assessment tools tailored specifically to obstetric populations that differ from other populations. For instance, both the Charlson/Romano comorbidity index or the Elixhauser comorbidity score and their adaptations are deficient in accounting for obstetric conditions, thereby limiting their ability to predict obstetric morbidity or mortality.
The Obstetric Comorbidity Index has undergone thorough examination and validation across multiple nations. These findings collectively demonstrate the index's capacity for moderate to high predictive accuracy in anticipating maternal morbidities, accompanied by a commendable discriminative performance.
However, within the context of Thailand, investigations concerning the Obstetric Comorbidity Index and its association with perioperative complications or morbidities in postpartum hemorrhage patients undergoing cesarean delivery remain unexplored. Therefore, this study aims to elucidate the correlation between the Obstetric Comorbidity Index and severe maternal morbidity, while also scrutinizing the prevalence of comorbidities during the perioperative period among patients undergoing cesarean delivery at the largest University hospital, in THAILAND. Predicting the rate of maternal morbidity would be advantageous for facilitating preparation and augmenting awareness of complications during the perioperative period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with postpartum hemorrhage with severe maternal morbidity | Patients with either one of severe maternal morbidity (severe hemorrhage, hypertension/neurologic, renal, sepsis, pulmonary, cardiac, intensive care unit, and anesthesia complications) |
| |
| Patients with postpartum hemorrhage without severe maternal morbidity | Patients without the severe maternal morbidity conditions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Obstetric comorbidity index | Other | Obstetric comorbidity index score |
|
| Measure | Description | Time Frame |
|---|---|---|
| The prediction of severe maternal morbidity using obstetric comorbidity index | The prediction of severe maternal morbidity using obstetric comorbidity index presented in C-statistic (AUC of ROC) | in 72 hours after cesarean delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of blood transfusion | Perioperative red blood cells transfusion in units | in 72 hours after cesarean delivery |
| Quantity of postpartum hemorrhage | Quantity of postpartum hemorrhage in ml. |
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Inclusion Criteria:
The patients underwent cesarean delivery with the diagnosis of postpartum hemorrhage (ICD-10 coding O72.1)
Exclusion Criteria:
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The chart of patients who underwent cesarean delivery with the diagnosis of postpartum hemorrhage (bleeding >, = 1,000 ml) and gestational age of more than 24 weeks.
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| Name | Affiliation | Role |
|---|---|---|
| Patchareya Nivatpumin, M.D. | Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok THAILAND | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Siriraj Hospital | Bangkok | 10700 | Thailand |
The investigators may balance the potential benefits and risks for each request and then provide the data that could be shared, together with the permission from the hospital director.
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| ID | Term |
|---|---|
| D006473 | Postpartum Hemorrhage |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| in 24 hours after cesarean delivery |
| Cause of postpartum hemorrhage | Main cause of postpartum hemorrhage | in 24 hours after cesarean delivery |
| Rate of ICU admission | Rate of intensive care unit admission | in 24 hours after cesarean delivery |
| Rate of Postoperative complications | Post operative complications eg. congestive heart failure, TRALI, acute kidney injury | in 72 hours after cesarean delivery |
| Neonatal Apgar score | Neonatal Apgar score from 0 - 10 | at 1-minute and 5-minute after delivery |
| Rate of maternal mortality | Maternal death rate | in 72 hours after cesarean delivery |
| D011644 | Puerperal Disorders |
| D014592 | Uterine Hemorrhage |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |