Nephroprotective Effect of Nicorandil in Type 2 Diabetes Mellitus

Clinical Study Evaluating the Nephroprotective Effect of Nicorandil in Patients With Type 2 Diabetes Mellitus

This study aims to evaluate the possible nephroprotective effect of nicorandil in patients with type 2 diabetes mellitus .

Inclusion Criteria:

• Patients newly diagnosed with T2DM with diet control and good glycemic index ( Hb A1C< 7 )
• Age range between 18 and 60 years old.
• Both sexes.
• Stage 1and Stage 2 CKD according to KDIGO .
• Controlled HTN .

Exclusion Criteria:

• Pregnant and lactating females.
• Patients with hypersensitivity to nicorandil.
• Other Causes of CKD or Nephropathy eg : Uncontrolled HTN , Renal Malignancy , collagen disease as Amyloidosis and some autoimmune disease as ( SLE and Rh.fever ) .
• Uncontrolled HTN and its antihypertensive medications ( ACEI , ARB ) and other antihypertensive medications .
• Patients receiving nephrotoxic drugs as aminoglycosides, non-steroidal anti inflammatory drugs and contrast media.