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The study addresses the pressing issue of overweight and obesity among breast cancer patients, which exacerbates recurrence rates and mortality risks. Its primary objective is to assess the efficacy of two intervention models, the Diet, Exercise, and Mindfulness (DEM) model and the Diet and Exercise (DE) model, in facilitating weight loss, enhancing self-efficacy, mindfulness, and quality of life. The anticipated outcomes include long-term engagement in online self-learning, overcoming the limitations of ineffective self-management learning, and empowering healthcare professionals with scenario-based teaching materials. Through online platforms, patients can learn and review without constraints, ultimately achieving a holistic balance among physical, mental, and spiritual health.
[Research Background] Breast cancer ranks first among cancers in women worldwide, with overweight and obesity being one of the high-risk factors for breast cancer. Moreover, overweight individuals within the breast cancer patient population also face higher recurrence rates and mortality risks. Assisting overweight or obese breast cancer women in weight loss to promote their well-being was the initial idea behind this study. The most common weight loss strategies include dietary management and regular exercise. In recent years, more studies have shown that effective weight loss also requires psychological interventions. Therefore, this study will combine dietary, exercise, and mindfulness-related interventions to assist breast cancer patients in more effective weight management.
[Research Objectives] To compare the effectiveness of two intervention measures, the Diet, Exercise, and Mindfulness (DEM) model and the Diet and Exercise (DE) model, on weight loss, self-efficacy, mindfulness tendency, and quality of life.
[Research Method] The study will involve a quantitative study, which plans to carry out a randomized controlled trial (RCT). This trial will compare the effects of two intervention measures, the DEM model and the DE model, on weight loss, self-efficacy, mindfulness tendency, and quality of life.
[Expected Results] Through the intervention provided by this study, patients can engage in long-term online self-learning and supplementary learning after returning home, reducing the limitations of ineffective self-management learning caused by negative emotions, treatment side effects, and sequelae in the early stages of cancer. Healthcare professionals can also use scenario-based teaching materials produced by this study to guide breast cancer survivors with ineffective weight self-management skills in practicing the necessary skills. Additionally, through online learning, patients can learn and review without pressure, saving time on transportation, easing carbon foot print and relearning effective weight management skills; even if they have faced major life threats in the past, they can turn adversity into blessings, achieving a balance among physical, mental, and spiritual health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DEM model | Experimental | subjects participate diet, exercise and mindfulness programs |
|
| DE model | Active Comparator | subjects participate diet and exercise programs |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary program | Behavioral | Participants will attend 8-week online dietary course. In addition to weekly classes, participants are required to photograph each meal. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Physiological indicator I | BMI in kg/m2 (weight in kilograms divided by height in meters squared) | baseline, 8 weeks, 24 weeks, 48 weeks |
| Physiological indicator II | Waist circumference in centimeter | baseline, 8 weeks, 24 weeks, 48 weeks |
| Physiological indicator III | Body fat in percentage | baseline, 8 weeks, 24 weeks, 48 weeks |
| Physiological indicator IV | Muscle mass in kilograms | baseline, 8 weeks, 24 weeks, 48 weeks |
| Food Intake Frequency | Food Frequency Questionnaire | baseline, 8 weeks, 24 weeks, 48 weeks |
| Mindful Awareness Attention | The minimum value is 1 and maximum value is 6, and higher scores mean a better outcome. | baseline, 8 weeks, 24 weeks, 48 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Weight Efficacy Lifestyle Questionnaire | The minimum value is 0 and maximum value is 10, and higher scores mean a better outcome. | baseline, 8 weeks, 24 weeks, 48 weeks |
| European Organization for Research and Treatment of Cancer Quality of Life Questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Associate Professor | National Yang Ming Chiao Tung University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Yang Ming Chiao Tung University | Taipei | 112 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42290885 | Derived | Lin YF, Lokmic-Tomkins Z, Chang KJ, Hu ML, Feng HC, Cheng CP, Shun SC, Chang HJ, Hou IC. Preliminary effects of an online diet, walking, and mindfulness-integrated lifestyle intervention for breast cancer survivors with overweight or obesity: A pilot randomized controlled trial. Asia Pac J Oncol Nurs. 2026 Apr 28;13:100966. doi: 10.1016/j.apjon.2026.100966. eCollection 2026 Dec. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 18, 2026 | |
| Reset | May 8, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 18, 2026 | May 8, 2026 |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Exercise program | Behavioral | Everyday walking steps more than 4000 steps. To accurately track participants' daily step counts, the research team provided quailfied pedometers. |
|
| Mindfulness program | Behavioral | Participants will attend 8-week online mindfulness course. In addition to weekly classes, participants practiced mindfulness individually for 5 minutes each day and maintained a mindfulness diary. |
|
|
| baseline, 8 weeks, 24 weeks, 48 weeks |
| Breast Cancer-Specific Quality of Life Questionnaire | The minimum value is 1 and maximum value is 4, and lower scores mean a better outcome. | baseline, 8 weeks, 24 weeks, 48 weeks |
| D017437 |
| Skin and Connective Tissue Diseases |
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |