Blood concentrations of Ciprofol were measured at different time points after single injection in patients with hypoproteinemia

This study was a single-center, interventional clinical study. Patients with different plasma albumin levels were selected before surgery and induced by a single injection of Ciprofol at a depth of 0.3 mg/kg. 2ml of venous blood was collected before and 0.5, 1, 2, 3, 5, 8, 15, 30min, 1h, 2h and 4h after administration. The pharmacokinetics of Ciprofol were studied by measuring the concentration of Ciprofol in blood.

Inclusion Criteria:

• Patients with moderate to severe hypoproteinemia (albumin < 30g/L, protein detection time uniformly within three days before surgery）
• Weight greater than 45kg, BMI20-24
• The ASA rating is Class I or Class II

Exclusion Criteria:

• Severe liver dysfunction
• Severe renal dysfunction
• Patients with ASA grade III and above
• Known allergy to eggs, soy products, opioids and their relief drugs, propofol
• Emergency surgery