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Campylobacter bacteria, a Gram-negative bacillus commensal in the digestive tract of many animals and mainly responsible for human infections with digestive origins, has been little studied in the field of osteoarticular infections (OAI). Campylobacter spp. are, however, well described, mainly for C. fetus, and pose a dual therapeutic problem: i) a capacity for persistence due to the capacity of most strains to form biofilm; and ii) potential resistance to many antibiotics. The management of IOA caused by Campylobacter spp. is not codified, and is based on small series of cases reported in the literature.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Management, progression and risk factors for failure of BJI caused by Campylobacter spp. | Adult patients treated for prosthetic joint infection caused by Campylobacter spp. between 01/01/2013 and 12/31/2022 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Management, progression and risk factors for failure of BJI caused by Campylobacter spp. | Other | Description of demographic data (sex, age), comorbidities (ASA and Charlson scores), orthopedic and septic history, and surgical and medical management (antibiotic therapy) |
| Measure | Description | Time Frame |
|---|---|---|
| Outcome of Campylobacter spp. BJI, measured as the proportion of treatment failure. | Treatment failure will be defined as: i) infection persistence under appropriate antimicrobial therapy; ii) infection relapse; iii) need for unplaned surgery; iv) superinfection and/or v) infection-related death | Outcome will be measure at 1 year. For patients lost of follow-up or followed-up less than a year, the date of last visit will be used for survival curve analysis . |
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Inclusion Criteria:
Exclusion Criteria:
-
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Adult patients treated for prosthetic joint infection caused by Campylobacter spp. between 01/01/2013 and 12/31/2022
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service des maladies infectieuses et tropicales - Hôpital de la Croix-Rousse | Recruiting | Lyon | 69317 | France |
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| Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp. | Other | Failure of treatment: defined according to a composite criterion bringing together
|
|
| ID | Term |
|---|---|
| D002169 | Campylobacter Infections |
| ID | Term |
|---|---|
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D012307 | Risk Factors |
| ID | Term |
|---|---|
| D012306 | Risk |
| D011336 | Probability |
| D013223 | Statistics as Topic |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D015984 | Causality |
| D015981 | Epidemiologic Factors |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D017531 | Health Care Evaluation Mechanisms |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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