The purpose of the study is to examine the feasibility and acceptability of an exercise and nutrition "prehabilitation" program for patients preparing for pancreatic cancer resection (removal).

Inclusion Criteria:

• Age 18 years or older
• Biopsy-proven pancreatic ductal adenocarcinoma (PDAC), borderline resectable at diagnosis
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Undergoing neoadjuvant chemotherapy with treatment plan including chemoradiation therapy and surgical resection
• Ability to read and speak English

Exclusion Criteria:

• Regular engagement in RT (2x/week targeting all major muscle groups)
• Screen failure for exercise safety based on PAR-Q
• Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
• Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT
• Numeric pain rating scale greater than or equal to a 7 out of 10
• Myopathic or rheumatologic disease that impacts physical function