This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis. The tissue marker profile of patient-derived organoids studied by gene expression, immunohistochemistry, and cytokine production profile will be compared with that of controls in order to test for the presence of specific biomarkers.

Inclusion Criteria:

• More than 18 years of age;
• Ability to understand and sign an informed consent form;
• Clinical indication for intestinal and/or synovial biopsy;
• Only for SpA patients group: meeting ASAS classification criteria.

Exclusion Criteria:

• Actively treated cancer;
• Severe comorbidities that, in the investigator's opinion, may affect the quality of samples for planned experimental applications;
• Only for patients undergoing ileal-colic biopsy: history of colorectal cancer disease, celiac disease;
• Only for patients undergoing a synovial biopsy: septic arthritis.

Patients affected by Spondyloarthtitis. Controls with inflammatory or non-inflammatory conditions.