An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.

PRIMARY OBJECTIVE:

I. High-resolution single-cell profiling of Cancer-associated fibroblasts (CAFs) in Human papillomavirus (HPV)+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) and metastatic lymph nodes.

OUTLINE: This is an observational study.

Patients undergo photography, blood sample collection, tissue collection and have their medical records reviewed on study.

Inclusion Criteria:

• Diagnosis/disease status: New diagnosis of head and neck cancer
• Allowable type and amount of prior therapy: No prior treatment
• Age ≥ 18 years.
• Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

• Patients who have had treatment of head and neck cancer