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Exploring the effect of remimazolam dose on paradoxical reactions in pediatric painless gastrointestinal endoscopy.
Exploring the effect of remimazolam dose on paradoxical reactions and sedation in pediatric painless gastrointestinal endoscopy, observing the performance and duration of paradoxical reactions, and analyze the factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group R1 | Experimental | The first induction dose of remimazolam is 0.1mg/kg. |
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| Group R2 | Experimental | The first induction dose of remimazolam is 0.2mg/kg. |
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| Group R3 | Experimental | The first induction dose of remimazolam is 0.3mg/kg. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remimazolam | Drug | Observe the incidence of paradoxical reactions after the first induction. |
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| Measure | Description | Time Frame |
|---|---|---|
| incidence of paradoxical reaction | observe the incidence of paradoxical reaction within 2 minutes | 2 minutes after first infusion of remimazolam |
| Measure | Description | Time Frame |
|---|---|---|
| performance and duration of paradoxical reaction | observe the performance and duration of paradoxical reaction within 2 minutes | 2 minutes after first infusion of remimazolam |
| dosage of sedative drugs |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| aihua Du, Dr. | Tongji Hospita | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji hospital | Wuhan | Hubei | 430030 | China |
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| ID | Term |
|---|---|
| C522201 | remimazolam |
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Total dose of the first administered plus supplemental doses of sedative drugs.
| First infusion until end of remimazolam administration |
| time records | anesthesia time, induction time, surgical time, awakening time, and recovery time | 1 day |
| Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] | respiratory suppression incidence;intraoperative blood pressure and heart rate changes: record the patient's intraoperative blood pressure, heart rate, and the use of related vasoactive drugs; postoperative adverse reactions: such as hypertension, hypotension, tachycardia, gastrointestinal symptoms, postoperative restlessness, etc. | 1 day |