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| Name | Class |
|---|---|
| Institute of Liver and Biliary Sciences | UNKNOWN |
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Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Isoflurane | Active Comparator | Drug- Isoflurane Dosage form- Inhalational, 1-2% Frequency- Continuously Duration- Throughout Intraoperative period |
|
| Propofol | Experimental | Drug- Propofol Dosage form- Intravenously, 2.5 mcg/ml target plasma concentration Frequency- Continuously Duration- Throughout Intraoperative period |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Target control infusion propofol | Drug | target control infusion of propofol for target plasma concentration 2.5mcg/ml and BIS 40-60 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of total Noradrenaline and vasopressin requirement between isoflurane and TCI propofol group in Living donor liver transplant recipients intraoperatively. | TCI propofol will provide more stable hemodynamics | INTRAOPERATIVELY |
| Measure | Description | Time Frame |
|---|---|---|
| To compare between the two groups mean arterial pressure during different phases of liver transplant recorded every 15 minutes | INTRAOPERATIVELY AT 15 MINUTES INTERVAL | |
| To compare between the two groups mean systemic vascular resistance during different phases of liver transplant recorded every 15 minutes |
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Inclusion Criteria:-Above 18 years of age who will undergo living donor liver transplant
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Exclusion Criteria: Refusal to consent
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abhinav Sharma, MD | Contact | 8860790151 | 91 | abhi27sh@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of liver and biliary sciences | Recruiting | Delhi | 110070 | India |
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Randomised, controlled, double blind
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| Inhalational isoflurane | Drug | Inhalational Isoflurane at concentration 1-2% |
|
| INTRAOPERATIVELY AT 15 MINUTES INTERVAL |
| To compare between the two groups cardiac output during different phases of liver transplant recorded every 15 minutes | INTRAOPERATIVELY AT 15 MINUTES INTERVAL |
| Total vasopressor requirement during reperfusion | Intraoperative |
| Peak dose of nordrenaline and vasopressin during different phases of liver transplant intraoperatively | Intraoperatively |
| QTc interval between the two groups during different phases of liver transplant measured every 15 minutes | Intraoperatively every 15 mins |
| Peak lactate levels intraoperatively | Intraoperatively |
| Postoperative Liver function tests ie Bilirubin and albumin | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Liver function tests ie AST and ALT | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Liver function tests ie GGT | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Liver function tests ie platelet count | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative coagulation profile | at 12, 24, 72 hours and day 7 postoperatively |
| Postoperative Renal function tests i.e. Blood urea and S.creatinine levels | at12, 24, 72 hours and day7 postoperatively |