Inpatient Penicillin Delabeling for Low-Risk Patients

Inpatient Penicillin Delabeling for Low-Risk Patients

This study seeks to enroll patients admitted to a children's hospital with identified penicillin allergy. A screening checklist is performed to identify patients with very low or low risk histories of penicillin allergy to offer direct oral challenges to the antibiotic class to de-label patient's with drug allergies.

This is a pilot study looking to utilize a novel criterion to identify low risk penicillin allergies for patients admitted to a children's hospital to evaluate safety and efficacy of direct oral challenges to patients with very low or low risk histories as identified in novel criterion.

Inclusion Criteria:

• Patients >2 years
• Patients identified via EMR as having a penicillin, amoxicillin, amoxicillin/clavulanic acid allergy

Exclusion Criteria:

• Female patients aged >8 years of age
• Patients with hemodynamic instability
• Patients identified with moderate or high risk histories per protocol
• Patients currently taking oral antihistamines in 48 hours prior to direct challenge
• Patients currently taking oral steroids in 48 hours prior to direct challenge
• Patients currently receiving medications for nausea, shortness of breath,