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Since there is conflicting and insufficient data regarding CH personality and addictive behaviour, the investigators will investigate risk- and reward seeking behaviour in people with cluster headache. If an increased tendency towards this behaviour is shown, it will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
Cluster headache is a severe primary headache disorder. In clinical anecdotes, people with cluster headache frequently report use of tobacco and illicit drugs. Furthermore, addictive behaviours and tattoos are considered to be more common in people with cluster headache than in the general population. The causality of these associations remains unclear. A common biological susceptibility has been proposed, predisposing people to both addictive behaviour and cluster headache. On the other hand, a role of illicit drug exposure in cluster headache pathophysiology has been suggested. The increased use of tobacco and illicit drugs could also reflect attempts to treat cluster headache attacks. In this explorative study the investigators will assess both subjective and objective measures reflecting addictive behaviour and risk- and reward seeking in cluster headache. This will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Episodic cluster headache | Patients diagnosed according to ICHD3 criteria with episodic cluster headache |
| |
| Chronic cluster headache | Patients diagnosed according to ICHD3 criteria with chroniccluster headache |
| |
| Migraine | Patients diagnosed according to ICHD3 criteria with migraine (MA and MO) |
| |
| Healthy controls | Healthy controls, sex- and age-matched without current diagnosis of headache disorder |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BART Task | Diagnostic Test | The Zuckerman's Sensation Seeking Scale version-V (SSS-V) - Four-factor score, The Barret Impulsiveness Scale (BIS), Gormally's Binge Eating Scale (BES), The World Health Organization-developed AUDIT (Alcohol Use Disorders Identification Test) screen, The CAGE questionnaire for substance abuse-adapted to include drugs, Gamblers Anonymous's 20 Questions (GA20), Hospital Anxiety and Depression Scale (HADS) |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in mean total score on the Zuckerman Sensation Seeking Scale between groups | Between group difference | One time-point |
| Difference in mean total number of pumps during second trial between groups | Between group difference | One time-point |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in mean scores on the array of psychometric tests between groups | Between group difference | One time-point |
| Difference in mean scores on the BART between groups and between the first and second BART within groups |
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Inclusion Criteria:
Exclusion Criteria:
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People with episodic (n=35) and chronic cluster headache (n=35) will be recruited from the Neurology outpatient clinic of Leiden University Medical Centre. Migraineurs (n=35) will be recruited from the LUMINA pool from people with migraine who have previously expressed interest in being contacted for future studies. Healthy controls (n=35) will be recruited from a pool of prior research-study participants, who have previously expressed interest in being contacted for future studies. We aim to achieve a 3:1 male:female ratio.
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| Name | Affiliation | Role |
|---|---|---|
| Rolf Fronczek, MD / PhD | Neurologist LUMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| LUMC | Leiden | South Holland | Netherlands |
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| ID | Term |
|---|---|
| D003027 | Cluster Headache |
| ID | Term |
|---|---|
| D051303 | Trigeminal Autonomic Cephalalgias |
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
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Average # of pumps, Exploded Balloons
| One time-point |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |