Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with pre-existing atherosclerotic cardiovascular disease | Among the total cohort, pregnant women with pre-existing atherosclerotic cardiovascular disease were selected (N=145,315). |
| |
| Matched cohort | Among the total cohort, 1:4 matched offspring born to women without pre-existent atherosclerotic cardiovascular disease using a propensity score were generated (N=581,260). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pre-existing atherosclerotic cardiovascular disease | Other | Presence of pre-existing atherosclerotic cardiovascular disease |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of post-partum MACCE | major adverse cardiac and cerebrovascular event | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of All-cause death | Death from any causes | up to 5 years |
| Occurence of myocardial infarction | Myocarrdial infarction | up to 5 years |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
All womens with live birth from Korea
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ki Hong Choi | Contact | 82-2-3410-3419 | cardiokh@gmail.com | |
| Danbee Kang, PhD | Contact | 82-2-2148-7197 | dbee.kang@skku.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ki Hong Choi, MD | Samsung Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41383953 | Derived | Kang D, Heo J, Choi KH, Park T, Sung JH, Park TK, Lee JM, Cho J, Yang JH, Song YB, Hahn JY, Choi SH, Gwon HC, Oh SY. Association of maternal pre-existing atherosclerotic cardiovascular disease and neonatal and long-term offspring outcomes: a nationwide mother-child paired cohort. Hum Reprod Open. 2025 Nov 25;2025(4):hoaf074. doi: 10.1093/hropen/hoaf074. eCollection 2025. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D050197 | Atherosclerosis |
| D011248 | Pregnancy Complications |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
Not provided
Not provided
Not provided
Not provided
Not provided
| Occurence of revascularization | percutaneous coronary intervention or coronary artery bypass grafting | up to 5 years |
| Occurence of stroke | Ischemic or hemorrhagic stroke | up to 5 years |
| Occurence of adverse pregnancy outcome | preterm delivery, pre-eclampsia or eclampsia, other hypertensive disorder of pregnancy, small-for-gestational-age, and gestational diabetes | At delivery |
| Occurence of major congenital malformation in offspring | congenital malformation in offspring | At delivery |
| Occurence of neonatal adverse events in offspring | transient tachypnea, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, bronchopulmonary dysplasia, and sepsis | within 30 days |
| Occurence of adverse infant events in offspring | admission to intensive care unit and occurrence of seizure events | Within 1 year |
| Occurence of neurodevelopmental disorders | autism spectrum disorder, attention-deficit/hyperactivity syndrome, cerebral palsy, any developmental delay including motor or cognitive delay, epileptic and febrile seizures and tics, and stereotypic behavior | up to 5 years |
| D000091642 | Urogenital Diseases |