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| Name | Class |
|---|---|
| The Second Hospital of Anhui Medical University | OTHER |
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Presently, the effects of perioperative temperature management on postoperative delirium remain ambiguous. This study endeavors to explore the influence of intraoperative temperature variations in elderly hip fracture patients on postoperative delirium.
At present, the pathophysiological mechanisms contributing to postoperative delirium in elderly hip fracture patients remain elusive, with predominant research concentrating on neural inflammation, neurotransmitter dysregulation, and metabolic irregularities. The influence of perioperative temperature management on postoperative delirium remains uncertain and may correlate with surgical modality and intraoperative temperature modulation. Hence, this study endeavors to juxtapose intraoperative temperature variations among elderly hip fracture patients, probing their ramifications on postoperative delirium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group C | No Intervention | Patients in Group C will be covered with a bedsheet intraoperatively without active warming methods employed. | |
| Group W | Experimental | Patients in Group W will have a 37°C forced-air warming blanket initiated upon entering the operating room to maintain their body temperature between 36-37 degrees Celsius. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3Mâ„¢ Bair Huggerâ„¢ Warming Unit | Device | Utilizing the 3M Temperature Management Unit to ensure intraoperative body temperature of elderly hip surgery patients remains consistent with their preoperative baseline, while patients in Group C receive no intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of postoperative delirium | Confusion Assessment Method (CAM) was recorded before surgery, 10 min after admission to PACU, before exiting the post-anesthesia care unit (PACU), and 1, 2, and 3 days after surgery. POD was diagnosed if the patient had at least one episode of delirium at these time points after surgery. The CAM diagnostic algorithm is based on four cardinal features of delirium: 1) acute onset and fluctuating course, 2) inattention, 3) disorganized thinking, and 4) altered level of consciousness. A diagnosis of delirium according to the CAM requires the presence of features 1, 2, and either 3 or 4. | Within 3 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of intraoperative hypothermia | Perioperative hypothermia was defined as a drop in core temperature below 36 ℃. Intraoperative tympanic membrane temperature was measured to record the incidence and duration of hypothermia. | During operation |
| Pleiotropic cytokine in the patient's serum |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongjian Wang, MD | Contact | +86 15806019263 | wanghj_a@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xianwen Hu, PhD | The Second Hospital of Anhui Medical University | Study Chair |
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Currently, it remains unclear how IPD sharing will be conducted.
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| D000084462 | Hyperthermia |
| D007035 | Hypothermia |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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Enrolled participants were randomly assigned to a control group (Group C) or a body temperature protection group (Group W) in a 1:1 ratio.
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Clinical trials and meta-analyses have identified the association between POD and increased perioperative levels of Interleukin-6 (IL-6), a pleiotropic cytokine that is both necessary and sufficient for postoperative memory decline in a preclinical model of POD. |
| Serum interleukin-6 (IL-6) levels before surgery and at 1, 2, and 3 days after surgery. |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001832 | Body Temperature Changes |
| D018882 | Heat Stress Disorders |
| D014947 | Wounds and Injuries |