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Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110. Data were collected on their clinical course prior to termination of pregnancy, using the last reported sFlt-1/PlGF ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sFlt-1/PlGF: 110-205 | Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 110-205. |
| |
| sFlt-1/PlGF: 206-654 | Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 206-654. |
| |
| sFlt-1/PlGF: 655-999 | Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF between 655-999. |
| |
| sFlt-1/PlGF > 1000 | Subjects with suspicion of preeclampsia, with gestational age between 24 - 36 6/7 weeks and sFlt-1/PlGF above 1000. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard of care | Diagnostic Test | No intervention. Clinical evolution was recorded, looking for perinatal complications. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Kidney injury | Creatinine level > 1.1 Doubling of creatinine levels when others causes had been excluded | From the moment of admission up until discharge after delivery, average 5 to 10 days |
| Hepatic enzyme abnormalities | Increase of liver enzyme to > twice the upper limit of normal | From the moment of admission up until discharge after delivery, average 5 to 10 days |
| HELLP Syndrome | Elevated liver enzymes Thrombocytopenia Hemolysis | From the moment of admission up until discharge after delivery, average 5 to 10 days |
| Growth restricted fetus | Fetal weight below 10th percentile and abnormal doppler Fetal weight below 3th percentile | From the moment of admission up until delivery, average 5 to 10 days |
| Stillbirth | Intrauterine fetal demise | From the moment of admission up until discharge after delivery, average 5 to 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects admitted with suspicion of preeclampsia, between 24 and 36 6/7 weeks with result of sFlt-1/PlGF before delivery.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Thomas H | Panama City | Panama |
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| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D006973 | Hypertension |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |