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Endoscopic retrograde cholangiopancreatography (ERCP) procedure is frequently encountered in non-operating room anesthesia applications (NORA). It is a procedure that requires deep sedation and analgesia in terms of gastroenterologist and patient comfort. Dexmedetomidine, which is increasingly used in NORA applications, comes to the fore because it does not cause respiratory depression, reduces the stress response, and provides hemodynamic stability. This study aims to compare the effects of dexmedetomidine-propofol (DP) and remifentanil-propofol (RP) combinations on hemodynamic stability, rapid recovery, and patient comfort in patients who underwent ERCP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Dex | Active Comparator | Group Dex received 0.5 mcg/kg of dexmedetomidine IV for 10 minutes, then dexmedetomidine infusion was started at 0.1-0.7 mcg/kg/h. Propofol 1 mg/kg was administered after waiting for 5 minutes for adequate sedation to develop due to dexmedetomidine's delayed onset of action. |
|
| Group Remi | Active Comparator | Group RP received remifentanil 0.1 mcg/kg intravenously for 2 minutes, then remifentanil infusion was started at 0.01-0.1 mcg/kg/min. After waiting 2 minutes to develop a sufficient sedation level, 1 mg/kg of propofol was given. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Group DP received 0.5 mcg/kg of dexmedetomidine IV for 30 seconds, then dexmedetomidine infusion was started at 0.1-0.7 mcg/kg/h. Propofol 1 mg/kg was administered after waiting for 5 minutes for adequate sedation to develop due to dexmedetomidine's delayed onset of action. |
| Measure | Description | Time Frame |
|---|---|---|
| Agitation-Sedation | It will be evaluated with a Richmond Agitation-Sedation Scale. | 0 and 5 minutes after ERCP ends |
| Hemodynamic stability | Mean arterial pressure with non-invasive blood pressure monitoring (mmHg) | 5, 10, 15, 25, 35. minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Minimize drug dose | Amounts of medication administered throughout the procedure period will be collected. | 5, 10, 15, 25, 35. minutes |
| Patient comfort | It will be evaluated by nausea-vomiting and survey. |
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Inclusion Criteria:
-ASA 1-3
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baskent University Ankara Hospital | Ankara | Cankaya | 06490 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| Remifentanil | Drug | Group RP received remifentanil 0.1 mcg/kg intravenously for 30 seconds, then remifentanil infusion was started at 0.01-0.1 mcg/kg/min. After waiting 2 minutes to develop a sufficient sedation level, 1 mg/kg of propofol was given. |
|
| 30 minutes after ERCP ends |
| Rapid recovery | It will be evaluated with a Modified Aldrete Score. | 30 minutes after ERCP ends |
| D011422 |
| Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |