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By comparing the clinical manifestations, ABR parameters and cerebral cortex blood oxygen levels of chronic tinnitus patients and healthy subjects under two different body states, the peripheral-central correlation of chronic tinnitus patients was explored, and the modern scientific significance of the theory of "two ears connecting the brain" was initially expounded. On this basis, the immediate and cumulative effects and peripheral-central correlation of "dao qi tong luo" intervention in chronic tinnitus were observed, and the effective mechanism of "dao qi tong luo" treatment was explored.
The study will enroll 15 healthy subjects and 72 subjects with chronic tinnitus. Functional near infrared spectroscopy (fNIRS) will be used to examine specific brain regions, and ABR techniques will record auditory brainstem responses in chronic tinnitus patients and healthy subjects. Lateral comparison was made between chronic tinnitus patients and healthy subjects on the parameters of auditory brainstem response and the level of oxygen outside the cerebral cortex, and the data of the two were integrated to conduct correlation analysis and correlation analysis with clinical manifestations, so as to compare the correlation between peripheral and central auditory function in different body states. Subsequently, the chronic tinnitus subjects will undergo a course of acupuncture treatment. At the end of acupuncture and moxibustion treatment, the immediate and cumulative effects and peripheral - central correlation of "dao qi tong luo" intervention in chronic tinnitus were observed, and the effective mechanism of "dao qi tong luo" treatment was explored.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The "dao qi tong luo" group | Experimental | Subjects in the "dao qi tong luo" group will undergo acupuncture treatment, which is administered 10 times |
|
| The acupuncture group | Sham Comparator | Subjects in the acupuncture group will undergo acupuncture treatment, which is administered 10 times |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The "dao qi tong luo" group | Procedure | The "dao qi tong luo" group will accept acpuncture. Acupuncture will be performed at acupoints including TE17 (Yifeng), SI19 (Tinggong), GB2 (Tinghui), TE5 (Waiguan), TE3 (Zhongzhu) and etc. Among them, the "dao qi tong luo" group will make patients feel qi. |
| Measure | Description | Time Frame |
|---|---|---|
| Tinnitus Handicap Inventory (THI) | Tinnitus Handicap Inventory is based on relevant expert consensus. THI scores range from 0 to 100, with the higher the score, the more severe the condition | at baseline (pre-treatment),procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Tinnitus Evaluation Questionnaire (TEQ) | Tinnitus Evaluation Questionnaire is based on relevant expert consensus. TEQ scores range from 0 to 21, with the higher the score, the more severe the condition | at baseline (pre-treatment), procedure |
| Auditory Brainstem Response (ABR) |
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Inclusion Criteria:
Inclusion criteria for patients with chronic tinnitus
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Da Jiang, M.M | Contact | 18890261521 | jddyx2023@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jie Zhou, M.D | The Third Affiliated hospital of Zhejiang Chinese Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Third Affiliated Hospital of Zhejiang Chinese Medical University | Recruiting | Hangzhou | 310000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40018352 | Derived | Jiang D, Huang XH, Fang K, Zhao MH, Li Y, Hu HT, Fang LQ, Gao H, Zhou J. Peripheral-central correlation study of acupuncture for chronic tinnitus study protocol for a randomized controlled trial. Front Med (Lausanne). 2025 Feb 13;12:1543023. doi: 10.3389/fmed.2025.1543023. eCollection 2025. |
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|
| The acupuncture group | Procedure | The acupuncture group will accept acpuncture. Acupuncture will be performed at acupoints including TE17 (Yifeng), SI19 (Tinggong), GB2 (Tinghui), TE5 (Waiguan), TE3 (Zhongzhu) and etc. The acupuncture group will not feel qi. |
|
Auditory Brainstem Response is based on relevant expert consensus |
| at baseline (pre-treatment), procedure |
| Functional Near-Infrared Spectroscopy (Fnirs) | Functional Near-Infrared Spectroscopy is based on relevant expert consensus | at baseline (pre-treatment), procedure |
| ID | Term |
|---|---|
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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